Endobronchial Smooth Muscle Tumors: A Series of Five Cases Highlighting Pitfalls in Diagnosis

Journal of Pathology and Translational Medicine
Tripti NakraDeepali Jain

Abstract

Primary endobronchial smooth muscle tumors (SMTs), which are extremely rare, include endobronchial leiomyomas and leiomyosarcomas. Clinically, SMTs present with signs and symptoms of bronchial obstruction, and lack specific radiological findings. Thus, histopathological examination is required for accurate diagnosis as well as for tumor grading. We examined the histomorphological and immunohistochemical features of endobronchial SMTs and highlighted pitfalls in diagnosis, particularly when using small biopsies. Cases of primary endobronchial SMTs diagnosed at our Institute over the last 6 years (2012-2017) were retrieved from the departmental archives. Histopathological features and immunohistochemistry performed for establishing the diagnosis were reviewed. Five cases of SMTs occurring in endobronchial locations were identified. These included three cases of leiomyoma, and two cases of leiomyosarcoma. The age distribution of patients ranged from 13 to 65 years. Leiomyomas showed more consistent staining with smooth muscle markers (smooth muscle actin, desmin, and smooth muscle myosin heavy chain), while tumors of higher grade showed variable, focal staining, leading to erroneous diagnosis, especially on small biopsies. The dia...Continue Reading

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Citations

Sep 23, 2020·Journal of Bronchology & Interventional Pulmonology·Mohammad Abu-HishmehOleg Epelbaum
May 10, 2021·Chest·Christina TriantafyllidouKarin Cederquist
Nov 10, 2020·Journal of Thoracic Imaging·Matthew R McCannJustin T Stowell

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Methods Mentioned

BETA
surgical resection
biopsy
biopsies

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