Endocan, Novel Potential Biomarker for Systemic Sclerosis: Results of a Pilot Study

Journal of Clinical Laboratory Analysis
Paul BălănescuGheorghe Andrei Dan

Abstract

Systemic sclerosis (Ssc) is an autoimmune disease characterized by vascular alterations of small arteries and microvessels with subsequent tissue fibrosis. Endocan is expressed by endothelial cells and associated with endothelial dysfunction; therefore it could be a potential biomarker for Ssc patients. Twenty-one Ssc patients and 20 sex- and age-matched healthy controls were recruited for the study. Serum endocan levels were determined using ELISA method in all patients and controls. Serum endocan levels were superior in Ssc patients (median 2.53 (1.10-7 ng/ml)) compared with controls (0.79 (0-2 ng/ml), P < 0.05). Higher serum endocan expression was seen in diffuse Ssc subset and associated with the presence of digital ulcers and daily Raynaud's phenomenon (P < 0.05). Higher serum endocan levels were associated with a modified Rodnan skin score >14 and longer disease duration (P < 0.05). Values of areas under the receiver operating curves showed that serum endocan had good discriminative power for Ssc diagnosis, differentiating diffuse from limited subset type and differentiating patients with modified Rodnan skin score above and under 14 (area under curve: 0.94, 0.81, 0.75, respectively). The results of this pilot study sugge...Continue Reading

References

Aug 23, 1996·The Journal of Biological Chemistry·P LassalleA B Tonnel
Jul 5, 2003·Rheumatic Diseases Clinics of North America·Nicholas A FlavahanMaqsood A Chotani
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bogdan Dragos GrigoriuPhilippe Lassalle
Jul 2, 2008·Digestive Diseases and Sciences·Geng-Wen HuangXiang Ding
Aug 6, 2008·World Journal of Gastroenterology : WJG·Li ZuoYuan Wang
Feb 28, 2009·Arthritis and Rheumatism·S BernatskyA E Clarke
Jan 28, 2010·Histopathology·Xavier LeroyPhilippe Lassalle
Apr 13, 2010·Annals of Surgical Oncology·Ni LiuJia-fu Ji
May 10, 2011·Autoimmunity Reviews·Vasiliki LiakouliRoberto Giacomelli
Nov 2, 2013·Journal of the American Academy of Dermatology·Ilknur BaltaYasemin Gulcan Kurt
Apr 29, 2014·Microvascular Research·Dunja M MihajlovicTatjana N Cebovic
May 17, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Paul BălănescuGheorghe Andrei Dan
Feb 6, 2015·Angiology·Sevket BaltaAtila Iyisoy

❮ Previous
Next ❯

Citations

Oct 9, 2015·Atherosclerosis·Sevket BaltaAtila Iyisoy
Feb 18, 2018·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Andrei Mihai VoiosuTheodor Alexandru Voiosu
Feb 23, 2020·Angiology·Ana Rita LeiteAdelino Leite-Moreira
May 10, 2020·BioMed Research International·Kornelia Kuźnik-TrochaKrystyna Olczyk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne
P BălănescuGh A Dan
Clinica Chimica Acta; International Journal of Clinical Chemistry
Giuseppe LippiGiancesare Guidi
© 2021 Meta ULC. All rights reserved