Endocannabinoid-LTP Mediated by CB1 and TRPV1 Receptors Encodes for Limited Occurrences of Coincident Activity in Neocortex

Frontiers in Cellular Neuroscience
Yihui CuiLaurent Venance

Abstract

Synaptic efficacy changes, long-term potentiation (LTP) and depression (LTD), underlie various forms of learning and memory. Synaptic plasticity is generally assessed under prolonged activation, whereas learning can emerge from few or even a single trial. Here, we investigated the existence of rapid responsiveness of synaptic plasticity in response to a few number of spikes, in neocortex in a synaptic Hebbian learning rule, the spike-timing-dependent plasticity (STDP). We investigated the effect of lowering the number of pairings from 100 to 50, and 10 on STDP expression, using whole-cell recordings from pyramidal cells in rodent somatosensory cortical brain slices. We found that a low number of paired stimulations induces LTP at neocortical layer 4-2/3 synapses. Besides the asymmetric Hebbian STDP reported in the neocortex induced by 100 pairings, we observed a symmetric anti-Hebbian LTD for 50 pairings and unveiled a unidirectional Hebbian spike-timing-dependent LTP (tLTP) induced by 10-15 pairings. This tLTP was not mediated by NMDA receptor activation but requires CB1 receptors and transient receptor potential vanilloid type-1 (TRPV1) activated by endocannabinoids (eCBs). eCBs have been widely described as mediating short- ...Continue Reading

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Citations

Aug 28, 2020·Frontiers in Molecular Neuroscience·Charlotte PietteLaurent Venance
Jan 2, 2021·Frontiers in Pharmacology·Felipe PatricioIlhuicamina Daniel Limón
Aug 24, 2020·Neuroscience·Marco FuenzalidaAndrés E Chávez
Dec 1, 2020·Frontiers in Cellular Neuroscience·Charlotte PietteLaurent Venance
Jun 14, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gerwyn MorrisAndre F Carvalho
Aug 4, 2021·Neuropharmacology·Bryony Laura Winters, Christopher Walter Vaughan

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