Endocannabinoid System Contributes to Liver Injury and Inflammation by Activation of Bone Marrow-Derived Monocytes/Macrophages in a CB1-Dependent Manner

The Journal of Immunology : Official Journal of the American Association of Immunologists
Ping MaiLiying Li

Abstract

Hepatic injury undergoes significant increases in endocannabinoidsand infiltrations of macrophages, yet the concrete mechanisms of changes in endocannabinoids and the functions of macrophage-expressed cannabinoid receptors (CBs) are unclear. Biosynthetic and degradative enzymes of endocannabinoids revealed a significant change in human fibrotic liver. Meanwhile, we showed dynamic changes of these enzymes and CBs (CB1 and CB2) from 1 to 56 d in carbon tetrachloride-induced murine liver injury. Biosynthetic enzymes (N-acylphosphatidyl-ethanolamine selective phospholipase D and diacylglycerol lipase-α) and CBs were markedly increased, whereas degradative enzymes (fatty acid amidohydrolase and monoacylglycerol lipase) were downregulated. Moreover, these enzymes intimately correlated with the fibrosis parameter [procollagen α1(III)]. Bone marrow-derived monocytes/macrophages (BMM) expressed CBs. Interestingly, CB1 but not CB2 mediated BMM migration through a Boyden chambers assay, and the effect depended on the G(α)i/o/RhoA/ROCK signaling pathway. ICR mice were lethally irradiated and received BM transplants from enhanced GFP transgenic mice. Four weeks later, mice of BM reconstruction were subjected to carbon tetrachloride-induced ...Continue Reading

References

Jan 25, 2000·The Journal of Biological Chemistry·S L Friedman
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoonkyung DoPrakash S Nagarkatti
Oct 7, 2004·Neuropharmacology·Allyn C HowlettLinda J Porrino
May 23, 2006·Nature Medicine·Fatima Teixeira-ClercSophie Lotersztajn
Apr 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sören V SiegmundRobert F Schwabe
May 26, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Magali Gary-BoboMohammed Bensaid
Nov 3, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·A Mallat, S Lotersztajn
Nov 17, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sören V Siegmund, Robert F Schwabe
Nov 22, 2007·The Journal of Pharmacology and Experimental Therapeutics·Javier Muñoz-LuqueWladimiro Jiménez
Mar 11, 2008·Lancet·Detlef Schuppan, Nezam H Afdhal
May 1, 2008·Nature Reviews. Drug Discovery·Vincenzo Di Marzo
Aug 16, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Leila MoeziSamuel S Lee
Mar 17, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Paolo CaraceniMauro Bernardi
Mar 21, 2009·Psychopharmacology·Bernard Le FollSteven R Goldberg
Jan 22, 2010·The Journal of Pharmacology and Experimental Therapeutics·Erinn S Raborn, Guy A Cabral
Feb 6, 2010·Science·Frederic GeissmannKlaus Ley
Jan 22, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joseph TamGeorge Kunos
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Bani MukhopadhyayGeorge Kunos
Jul 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexandre LouvetSophie Lotersztajn
Dec 14, 2011·Cellular & Molecular Immunology·Ruonan XuFu-Sheng Wang
Mar 1, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhen HanLiying Li
Mar 24, 2012·Science·Christian SchulzFrederic Geissmann
Sep 18, 2012·Gastroenterology·Paul Kubes, Wajahat Z Mehal
Nov 28, 2012·Biochemical Society Transactions·Alan Hall
Mar 12, 2013·Prostaglandins & Other Lipid Mediators·B M FonsecaN A Teixeira
Apr 5, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jean-Philippe PradereRobert F Schwabe
Apr 10, 2013·Journal of Hepatology·Ariane MallatSophie Lotersztajn
Apr 27, 2013·Nature·Thomas A WynnJeffrey W Pollard
Oct 12, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hyo-Jung KwonBin Gao

❮ Previous
Next ❯

Citations

Jan 10, 2018·Clinical Reviews in Allergy & Immunology·Min LianXiong Ma
Oct 9, 2018·Cardiovascular Research·Maximilian J SchlossSabine Steffens
Jun 24, 2017·Scientific Reports·Silvana Y Romero-ZerboFrancisco J Bermúdez-Silva
May 29, 2018·Immunologic Research·Le YangLiying Li
Dec 21, 2018·Nature Reviews. Gastroenterology & Hepatology·Jordi Gracia-SanchoAnabel Fernández-Iglesias
Mar 15, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ji Hye Han, Wook Kim
May 10, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Da ChengXin Ni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.