Endocannabinoid system in Xenopus laevis development: CB1 receptor dynamics

FEBS Letters
B MigliariniCarnevali Oliana

Abstract

This study investigates for the first time the dynamics of endocannabinoid system appearance during low vertebrate Xenopus laevis development. We observed that the CB1 gene started to be expressed during the organogenesis period (+/- 1 dpf, st. 28) and expression persisted throughout the three further stages analyzed. Attention was focused on the localization of the CB1 messenger that was found both at the central level (in romboencephalon and in olfactory placods) and at the peripheral level (in the gastrointestinal tract) at +/- 3 dpf (st. 41), +/- 4 dpf (st. 46) and +/- 12 dpf (st. 49). We also considered the synthesis of CB1 protein that occurred from st. 41 onwards and, from this stage, we tested the receptor functionality in response to anandamide using cytosensor microphysiometry. CB1 functionality increased with development at both central and peripheral level. These data provide sufficient evidence to encourage further analysis on endocannabinoid physiological roles during embryonic and larval X. laevis growth.

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Citations

Nov 13, 2009·Developmental Neuroscience·G A BuznikovJ M Lauder
Oct 9, 2013·International Journal of Endocrinology·Erika CottonePatrizia Bovolin
Feb 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dirk CzesnikIvan Manzini
Oct 6, 2009·General and Comparative Endocrinology·Chiara Carla PiccinettiOliana Carnevali
Mar 18, 2008·Molecular and Cellular Endocrinology·E CottoneM F Franzoni
Feb 6, 2015·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Xiaona ZhengMorioh Kusakabe
Dec 2, 2009·Cell Biology International·Jader NonesStevens K Rehen
Feb 7, 2012·Molecular and Cellular Endocrinology·Natalia BattistaMauro Maccarrone
May 2, 2014·Frontiers in Endocrinology·Patrizia BovolinRosaria Meccariello
May 19, 2017·Development, Growth & Differentiation·Francesca OltrabellaSu Guo
Dec 17, 2008·Molecular and Cellular Endocrinology·B Migliarini, O Carnevali

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