PMID: 9630590Jun 19, 1998Paper

'Endocannabinoids' and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance

Biochimica Et Biophysica Acta
V Di Marzo

Abstract

The only endogenous substances isolated and characterised so far that are capable of mimicking the pharmacological actions of the active principle of marijuana, (-)-Delta9-tetrahydrocannabinol, are amides and esters of fatty acids. Some of these compounds, like anandamide (N-arachidonoylethanolamine) and 2-arachidonoylglycerol, act as true 'endogenous cannabinoids' by binding and functionally activating one or both cannabinoid receptor subtypes present on nervous and peripheral cell membranes. The metabolic pathways and molecular mode of actions of these metabolites, as well as their possible implication in physiopathological responses, are reviewed here.

References

Nov 1, 1991·Pharmacology, Biochemistry, and Behavior·B R MartinS J Ward
Jan 1, 1990·Progress in Lipid Research·H H SchmidV Natarajan
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·C CollinD L Alkon
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·B C PariaS K Dey
Oct 4, 1995·Biochemical and Biophysical Research Communications·T SugiuraK Waku
Jul 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·V Di Marzo, A Fontana
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·L FacciA Leon
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·S K DasS K Dey
Feb 24, 1995·The Journal of Biological Chemistry·D ShireP Ferrara
Mar 17, 1995·The Journal of Biological Chemistry·F DesarnaudD Piomelli
Jul 1, 1994·European Journal of Pharmacology·R PertweeR Mechoulam
Jun 10, 1994·Journal of Medicinal Chemistry·V AbadjiA Makriyannis
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·W A Devane, J Axelrod
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·H SchuelS Zimmerman
Dec 15, 1993·Biochemical and Biophysical Research Communications·L M BornheimM A Correia
Dec 1, 1993·Molecular Reproduction and Development·M C ChangH Schuel
Sep 1, 1993·Biochemical Pharmacology·D G Deutsch, S A Chin
Feb 9, 1993·European Journal of Pharmacology·E Fride, R Mechoulam
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C C FelderW A Devane
Oct 1, 1993·Journal of Medicinal Chemistry·L HanusR Mechoulam

❮ Previous
Next ❯

Citations

Aug 25, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhangyin MingJizhou Xiang
Jul 16, 2005·Analytical Biochemistry·Manjunath K RamaraoJames D Clark
May 7, 2003·Biochemical Pharmacology·Giorgio OrtarVincenzo Di Marzo
Dec 7, 2000·Chemistry and Physics of Lipids·T Sugiura, K Waku
Dec 7, 2000·Chemistry and Physics of Lipids·H S HansenG Petersen
Dec 7, 2000·Chemistry and Physics of Lipids·L De PetrocellisV Di Marzo
Jun 6, 2002·Chemistry and Physics of Lipids·Qian LiuNatsuo Ueda
Dec 31, 2002·Chemistry and Physics of Lipids·Harald H O SchmidEvgueni V Berdyshev
May 24, 2000·European Journal of Pharmacology·P Beaulieu1A S Rice
Oct 21, 2000·European Journal of Pharmacology·V Di MarzoB R Martin
Mar 29, 2001·European Journal of Pharmacology·S KagotaM Kunitomo
Jun 16, 2001·European Journal of Pharmacology·V Di MarzoJ J Fernandez-Ruiz
Feb 6, 2003·European Journal of Pharmacology·Ester FrideRaphael Mechoulam
Nov 27, 1998·European Journal of Pharmacology·R MechoulamV Di Marzo
Aug 1, 2002·Life Sciences·Osama M H HabayebJustin C Konje
Jul 4, 2001·Survey of Ophthalmology·D F WoodwardL J Kaplan
Apr 29, 2000·Prostaglandins & Other Lipid Mediators·N Ueda, S Yamamoto
Apr 29, 2000·Prostaglandins & Other Lipid Mediators·V Di MarzoT Bisogno
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Natsuo Ueda
Jul 13, 2001·Pharmacology & Therapeutics·A C Porter, C C Felder
May 21, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·E V Berdyshev
Sep 12, 2013·The Proceedings of the Nutrition Society·Maria Grazia Cascio
Oct 30, 2001·British Journal of Pharmacology·R CapassoV Di Marzo
May 12, 2000·European Journal of Biochemistry·M MacCarroneA Finazzi-Agrò
Mar 30, 2001·European Journal of Biochemistry·T BisognoV Di Marzo
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·A BergerV Di Marzo
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·D L BogerB F Cravatt
Jun 28, 2003·Neurotoxicity Research·José A RamosJavier Fernández-Ruiz
Sep 13, 2003·Lipids in Health and Disease·Nicola De MarchiVincenzo Di Marzo
Jan 26, 2010·PloS One·Jack C SipeJill Waalen
Mar 22, 2003·Clinical Pharmacokinetics·Franjo Grotenhermen
Dec 27, 2013·International Journal of Endocrinology·Thangesweran AyakannuJustin C Konje

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.