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Endocannabinoids are conserved inhibitors of the Hedgehog pathway

Proceedings of the National Academy of Sciences of the United States of America

Mar 4, 2015

Helena KhaliullinaSuzanne Eaton

Abstract

Hedgehog ligands control tissue development and homeostasis by alleviating repression of Smoothened, a seven-pass transmembrane protein. The Hedgehog receptor, Patched, is thought to regulate the availability of small lipophilic Smoothened repressors whose identity is unknown. Lipoprote...read more

Mentioned in this Paper

Cannabinoids
Metabolic Process, Cellular
Hedgehog Proteins
In Vivo
Biochemical Pathway
Integral Membrane Proteins
PTCH1
Inhibitors
Drosophila
Integral to Membrane
12
1
4
77
Paper Details
References
  • References51
  • Citations23
12345...
  • References51
  • Citations23
123

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Endocannabinoids are conserved inhibitors of the Hedgehog pathway

Proceedings of the National Academy of Sciences of the United States of America

Mar 4, 2015

Helena KhaliullinaSuzanne Eaton

PMID: 25733905

DOI: 10.1073/pnas.1416463112

Abstract

Hedgehog ligands control tissue development and homeostasis by alleviating repression of Smoothened, a seven-pass transmembrane protein. The Hedgehog receptor, Patched, is thought to regulate the availability of small lipophilic Smoothened repressors whose identity is unknown. Lipoprote...read more

Mentioned in this Paper

Cannabinoids
Metabolic Process, Cellular
Hedgehog Proteins
In Vivo
Biochemical Pathway
Integral Membrane Proteins
PTCH1
Inhibitors
Drosophila
Integral to Membrane
12
1
4
77

Similar Papers Found In These Feeds

Lipids & Membrane Homeostasis

The cellular membrane is composed of diverse lipid molecules that help maintain membrane integrity and homeostasis. Discover the latest research on Lipids & Membrane Homeostasis

Lipid Metabolism

Lipid metabolism is important in several cellular processes and functions including signal transduction. Disorders of lipid metabolism can occur impairing normal function. Here is the latest research on lipid metabolism and lipid disorders.

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Development

Patched regulates Smoothened trafficking using lipoprotein-derived lipids

DevelopmentNovember 13, 2009
Helena KhaliullinaSuzanne Eaton
Paper Details
References
  • References51
  • Citations23
12345...
  • References51
  • Citations23
123
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