Endocannabinoids in Body Weight Control

Pharmaceuticals
Henrike HornMarco Koch

Abstract

Maintenance of body weight is fundamental to maintain one's health and to promote longevity. Nevertheless, it appears that the global obesity epidemic is still constantly increasing. Endocannabinoids (eCBs) are lipid messengers that are involved in overall body weight control by interfering with manifold central and peripheral regulatory circuits that orchestrate energy homeostasis. Initially, blocking of eCB signaling by first generation cannabinoid type 1 receptor (CB1) inverse agonists such as rimonabant revealed body weight-reducing effects in laboratory animals and men. Unfortunately, rimonabant also induced severe psychiatric side effects. At this point, it became clear that future cannabinoid research has to decipher more precisely the underlying central and peripheral mechanisms behind eCB-driven control of feeding behavior and whole body energy metabolism. Here, we will summarize the most recent advances in understanding how central eCBs interfere with circuits in the brain that control food intake and energy expenditure. Next, we will focus on how peripheral eCBs affect food digestion, nutrient transformation and energy expenditure by interfering with signaling cascades in the gastrointestinal tract, liver, pancreas, ...Continue Reading

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Citations

Dec 5, 2018·Physiological Reports·Juliane R JohnstonGaylen L Edwards
Dec 24, 2019·Clinical and Experimental Pharmacology & Physiology·Helda TutunchiAlireza Ostadrahimi
Feb 23, 2020·Psychopharmacology·Cristian Bis-HumbertM Julia García-Fuster
Dec 29, 2019·International Journal of Molecular Sciences·Giulia ZuccariniGiorgio Roberto Merlo
Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Günter A MüllerTimo D Müller
Aug 15, 2019·Neurotoxicology·Stefania BonaccorsoFabrizio Schifano
Jun 3, 2021·International Journal of Molecular Sciences·Slavko KomarnytskySaradhadevi Varadharaj

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Methods Mentioned

BETA
sedation
pharmacotherapy

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