Endocannabinoids: losing inhibition to increase learning capacity?

Neuron
Stephen M Fitzjohn, Graham L Collingridge

Abstract

Recent work has implicated endocannabinoids in various forms of synaptic plasticity. In this issue of Neuron, Chevaleyre and Castillo describe a new mechanism whereby a CB1 receptor-mediated LTD of inhibitory synaptic transmission facilitates the subsequent induction of LTP in a narrow band of synapses surrounding a region of potentiated synapses.

Citations

Sep 4, 2008·Journal of Integrative Neuroscience·Bruce G Mockett, Sarah R Hulme
Sep 30, 2008·Bioorganic & Medicinal Chemistry Letters·Victoria MagriotiGeorge Kokotos
Apr 18, 2020·The Proceedings of the Nutrition Society·Mathieu Di MiceliSophie Layé

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