Jul 13, 2015

Endocannabinoids regulate mAChR-evoked theta rhythm IPSCs in hippocampus

BioRxiv : the Preprint Server for Biology
Ai-Hui TangBradley E Alger

Abstract

Exogenous cannabinoids can affect behaviorally relevant neuronal oscillations, but there is little evidence that endogenous cannabinoids (endocannabinoids, eCBs) can affect them, although it is unknown whether eCBs were generated during oscillations investigated in previous studies. In rat hippocampal slices, muscarinic receptor (mAChR) agonists stimulate the occurrence of persistent, rhythmic inhibitory post-synaptic currents (IPSC) activity and mobilize eCBs. We tested the hypothesis that mAChR-induced IPSCs would be modulated by concomitantly produced eCBs. With ionotropic glutamate receptors inhibited, mAChR agonist application triggered eCB-sensitive IPSCs that were enhanced in amplitude and frequency when a cannabinoid receptor antagonist was also present. There was also a highly significant increase in IPSC spectral power in the theta-frequency range. The data show that eCBs released by mAChRs modulate rhythmic IPSCs, and suggest that eCBs are candidate regulators of neuronal oscillations associated with eCB production in vivo.

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Mentioned in this Paper

Cannabinoids
Study
In Vivo
C15orf59 gene
Antagonist Muscle Action
Muscarinic receptor kinase
Cannabinoid Receptor Antagonists
Theta Rhythm
Genus Hippocampus
Induced Pluripotent Stem Cells

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