Endocannabinoids: some like it fat (and sweet too)

Journal of Neuroendocrinology
I MatiasVincenzo Di Marzo

Abstract

There is growing interest in the commercialisation of the CB(1) receptor antagonist Rimonabant in Europe for the treatment of obesity and the metabolic syndrome. Clinical trials have shown that CB(1) receptor blockers are able to reduce not only food intake but also abdominal adiposity and its metabolic sequelae. Accordingly, CB(1) receptors, and tissue concentrations of endocannabinoids sufficient to activate them, are present in all brain and peripheral organs involved in the control of energy balance, including the hypothalamus, nucleus accumbens, pancreas, adipose tissue, skeletal muscle and liver. At the central level, the endocannabinoid system seems to play a dual role in the regulation of food intake by hedonic and homeostatic energy regulation. At the peripheral level, the endocannabinoid system seems to behave as a system that reduces energy expenditure and directs energy balance towards energy storage into fat. The emerging role of the endocannabinoid system in energy balance at both central and peripheral levels will be discussed in this review.

References

Sep 7, 1995·Biochemical Pharmacology·M GuzmánJ A Ramos
Jul 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·V Di Marzo, A Fontana
May 20, 1999·European Journal of Pharmacology·J E GallateI S McGregor
Nov 8, 2001·Trends in Pharmacological Sciences·E Schlicker, M Kathmann
Nov 13, 2001·British Journal of Pharmacology·N Jamshidi, D A Taylor
Mar 12, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D CotaU Pagotto
Nov 20, 2003·Neuroreport·P B SparlingA Dietrich
Sep 24, 2004·British Journal of Pharmacology·Sonia A TucciTim C Kirkham
Nov 24, 2004·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y L LiuM J Stock
Apr 6, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J C SipeE Beutler
Jun 14, 2005·Neuropharmacology·Kevin M GamberThomas C Westfall
Jul 13, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Omar JbiloPierre Casellas
Oct 21, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shane T HentgesJohn T Williams
Nov 25, 2005·Endocrine Reviews·Uberto PagottoRenato Pasquali
Dec 21, 2005·Brain Research Reviews·Daniela CotaAllen S Levine
Jan 6, 2006·Histochemistry and Cell Biology·Régis RocheFranck Festy
Jan 21, 2006·European Journal of Pharmacology·Francisco Javier Bermúdez-SivaFernando Rodríguez de Fonseca
May 11, 2006·The Journal of Clinical Endocrinology and Metabolism·Isabel MatiasVincenzo Di Marzo
May 24, 2006·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·N PerwitzJ Klein
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Renato Malcher-LopesJeffrey G Tasker
Sep 13, 2006·Gut·V Di Marzo, A A Izzo
Dec 5, 2006·Trends in Endocrinology and Metabolism : TEM·Isabel Matias, Vincenzo Di Marzo
Dec 26, 2006·Cellular and Molecular Life Sciences : CMLS·V GasperiM Maccarrone
Jan 16, 2007·Biochemical and Biophysical Research Communications·Zhen Cheng YanZhi Ming Zhu
Feb 3, 2007·Molecular and Cellular Endocrinology·P CavuotoG A Wittert
Apr 12, 2007·Obesity·Marie-Paule GonthierRégis Roche
May 4, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hao HuangAnthony N van den Pol
May 15, 2007·European Journal of Pharmacology·Francisco Javier Bermudez-SilvaFernando Rodríguez de Fonseca
Jun 26, 2007·Experimental Cell Research·Luciano De PetrocellisVincenzo Di Marzo
Jun 28, 2007·American Journal of Physiology. Endocrinology and Metabolism·Andreas W HerlingWerner Kramer

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Citations

May 3, 2011·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Daurice A GrossniklausMelinda K Higgins
Jun 19, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S Fulton
Jun 19, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·V Di MarzoL Cristino
Oct 31, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alistair NunnJimmy D Bell
Dec 15, 2011·American Journal of Physiology. Endocrinology and Metabolism·Christopher J LynchJochen Antel
Dec 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Philip J Scarpace, Yi Zhang
Mar 1, 2010·Expert Review of Clinical Pharmacology·Rudolf Schicho, Martin Storr
Mar 3, 2009·Expert Opinion on Emerging Drugs·David R Janero, Alexandros Makriyannis
Jun 26, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rahul R Deshmukh, P L Sharma
Mar 17, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Denis RichardElena Timofeeva
Sep 28, 2014·Molecular and Cellular Endocrinology·Edgar Soria-GomezGiovanni Marsicano
Jun 22, 2012·PloS One·Claudio D'AddarioMauro Maccarrone
Oct 20, 2012·PloS One·Sheena E M LewisMauro Maccarrone
May 28, 2010·PloS One·Alexander ChoukèrGustav Schelling
Nov 8, 2014·Computational and Structural Biotechnology Journal·Nicola BernabòMauro Maccarrone
Oct 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G R FoisM Diana
Mar 17, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·André J Scheen, Nicolas Paquot
Aug 6, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sabatino MaioneVincenzo Di Marzo
Sep 22, 2009·Immunobiology·Ilona Kubajewska, Cris S Constantinescu
Apr 16, 2009·International Review of Psychiatry·Tim C Kirkham
Feb 13, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stéphanie MigrenneChristophe Magnan
Jan 17, 2014·The Journal of Pharmacology and Experimental Therapeutics·Anusha Penumarti, Abdel A Abdel-Rahman
Oct 16, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Silvia Graciela RuginskJose Antunes-Rodrigues

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