Endocardial border delineation during dobutamine infusion using contrast echocardiography

Echocardiography
Wilson MathiasThomas R Porter

Abstract

A significant percentage of pharmacologic stress echocardiograms produce suboptimal images despite the use of second harmonic imaging. Intravenous continuous infusion of myocardial ultrasound contrast may enhance endocardial border delineation during dobutamine-atropine stress echocardiography (DASE), improving wall-motion analysis. We prospectively studied 68 patients (41 males and 27 females), mean age 58 years, with DASE during intravenous infusion of contrast using second harmonic imaging. Dobutamine was infused in scalar doses of 5 microg/kg/min to 40 microg/kg/min, and atropine was administered in doses of up to 1 mg. We diluted 0.1 mL of perfluorocarbon-exposed sonicated dextrose albumin (PESDA) microbubbles into 80 mL of saline solution, which was used for continuous intravenous infusion. Blinded reviewers used a 16-segment model at rest and peak DASE to analyze segmental wall delineation in two sets of images for each patient, with and without contrast. An endocardial delineation score of 0-3 (nondelineated to excellent delineation) was given to each segment. An endocardial delineation score index (EDSI), the number of endocardial delineation scores for each set of images divided by 16, was created. The analysis of the...Continue Reading

Citations

May 9, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Eiichi HyodoJunichi Yoshikawa
Jul 7, 2007·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·T W GalemaF J Ten Cate
May 20, 2005·Echocardiography·Joicely M CostaWilson Mathias
Feb 1, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Ana Clara T RodriguesJosé L Andrade
Mar 4, 2006·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Thomas R PorterNicholas Kipshidze
Apr 20, 2005·Journal of the American College of Cardiology·Jeane M TsutsuiThomas R Porter
Jul 29, 2021·Arquivos brasileiros de cardiologia·José Carlos NicolauWilson Mathias Júnior

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