Endocardial endothelial cell hypertrophy takes place during the development of hereditary cardiomyopathy

Molecular and Cellular Biochemistry
D Jacques, G Bkaily

Abstract

Endocardial endothelial cells constitute a barrier between the circulating blood and ventricular cardiomyocytes. Although recently our group demonstrated the importance of this type of endothelial cells in excitation-secretion coupling, there is no information on whether this type of cells contributes to cardiac pathologies such as cardiac hypertrophy. Using the well-known model of human hypertrophy and heart failure, the UM-X7.1 hereditary cardiomyopathic hamster, our results showed that during the phase of necrosis and in the absence of cardiac hypertrophy, isolated endocardial endothelial cells underwent a significant increase in cell volume compared to cells isolated from age-matched normal hamsters. This increase of the volume of endocardial endothelial cells persisted during the development of cardiac hypertrophy in the hereditary cardiomyopathic hamster. These results demonstrate for the first time, that endocardial endothelial hypertrophy precedes the development of hypertrophy in hereditary cardiomyopathy and may, via its released factors, contribute to the development of cardiac hypertrophy. These results demonstrate the importance of endocardial endothelial cells in cardiac diseases such as hypertrophy. This type of ...Continue Reading

References

Oct 3, 1999·Methods in Enzymology·G BkailyP Pothier
May 8, 2003·Canadian Journal of Physiology and Pharmacology·Danielle JacquesClaudine Perreault
Apr 6, 2005·Journal of Molecular and Cellular Cardiology·Mirna ChahineWolfgang Scholz
May 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Masahiko KodaHisayoshi Fujiwara
Aug 12, 2006·Canadian Journal of Physiology and Pharmacology·Danielle JacquesChantale Provost
Sep 26, 2006·Canadian Journal of Physiology and Pharmacology·Danielle JacquesChantale Provost
May 10, 2007·Canadian Journal of Physiology and Pharmacology·Danielle Jacques, Dima Abdel-Samad
Jun 3, 2008·Canadian Journal of Physiology and Pharmacology·Jean-Claude HonoréPedro D'Orleans-Juste
Aug 5, 2008·Vascular Pharmacology·P D'Orléans-JusteE Simard
Aug 21, 2015·Canadian Journal of Physiology and Pharmacology·Ghassan BkailyDanielle Jacques
Jan 25, 2017·Methods in Molecular Biology·Ghassan BkailyDanielle Jacques
Jul 21, 2017·Canadian Journal of Physiology and Pharmacology·Ghassan Bkaily, Danielle Jacques
Jul 21, 2017·Canadian Journal of Physiology and Pharmacology·Danielle JacquesGhassan Bkaily
Jul 25, 2017·Canadian Journal of Physiology and Pharmacology·Danielle JacquesGhassan Bkaily
May 26, 2018·Nature Reviews. Cardiology·Zoltan UngvariAnna Csiszar
Jun 1, 2018·Oxidative Medicine and Cellular Longevity·Antonietta Gerarda GravinaAlessandro Federico
Jun 1, 2018·Oxidative Medicine and Cellular Longevity·Jingyuan SunLing Gao
Jun 6, 2018·Acta Pharmacologica Sinica·Maura KnappRongxue Wu

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Citations

Feb 8, 2019·Canadian Journal of Physiology and Pharmacology·Danielle JacquesGhassan Bkaily
Mar 22, 2019·Canadian Journal of Physiology and Pharmacology·Ghassan BkailyDanielle Jacques
Aug 28, 2020·Canadian Journal of Physiology and Pharmacology·Ghassan BkailyDanielle Jacques
Aug 28, 2021·Biomedicines·Ghassan BkailyDanielle Jacques

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