Abstract
Previous animal studies have demonstrated differences in perfusion and perfusion reserve between the subendocardium and subepicardium. 320-row computed tomography (CT) with sub-millimetre spatial resolution allows for the assessment of transmural differences in myocardial perfusion reserve (MPR) in humans. We aimed to test the hypothesis that MPR in all myocardial layers is determined by age, gender, and cardiovascular risk profile in patients with ischaemic symptoms or equivalent but without obstructive coronary artery disease (CAD). A total of 149 patients enrolled in the CORE320 study with symptoms or signs of myocardial ischaemia and absence of significant CAD by invasive coronary angiography were scanned with static rest and stress CT perfusion. Myocardial attenuation densities were assessed at rest and during adenosine stress, segmented into 3 myocardial layers and 13 segments. MPR was higher in the subepicardium compared with the subendocardium (124% interquartile range [45, 235] vs. 68% [22,102], P < 0.001). Moreover, MPR in the septum was lower than in the inferolateral and anterolateral segments of the myocardium (55% [19, 104] vs. 89% [37, 168] and 124% [54, 270], P < 0.001). By multivariate analysis, high body mass ...Continue Reading
References
Nov 1, 1977·Circulation Research·R J Bache, F R Cobb
Apr 1, 1978·Cardiovascular Research·J P Archie
Nov 1, 1977·Circulation·K A ReimerR B Jennings
Jul 1, 1993·Circulation·J CzerninH R Schelbert
Jun 1, 1996·The Journal of Clinical Investigation·H O SteinbergA D Baron
Jan 1, 1997·European Heart Journal·L ChoudhuryP G Camici
Feb 11, 1999·Journal of the American College of Cardiology·C S DuvernoyM Schwaiger
Apr 3, 2001·Cardiovascular Research·P ChareonthaitaweeP G Camici
May 10, 2001·Journal of the American College of Cardiology·J Al SuwaidiA Lerman
May 13, 2004·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Olaf M MuehlingNorbert Wilke
May 3, 2005·Journal of the American College of Cardiology·Thomas H SchindlerUlrich Solzbach
Mar 21, 2006·Journal of the American College of Cardiology·Thomas H SchindlerHeinrich R Schelbert
Oct 4, 2006·Physiological Reviews·Nico WesterhofPieter Sipkema
May 17, 2007·European Heart Journal·Ilse A C VermeltfoortAlbert C van Rossum
Nov 17, 2007·Investigative Radiology·Richard T GeorgeAlbert C Lardo
Jul 16, 2008·Journal of Hypertension·Kalina Kawecka-JaszczRobert P Banyś
Jul 16, 2008·Physiological Reviews·Dirk J Duncker, Robert J Bache
Oct 8, 2009·Circulation. Cardiovascular Imaging·Richard T GeorgeJoão A C Lima
Jun 15, 2010·JACC. Cardiovascular Imaging·Thomas H SchindlerVasken Dilsizian
Jun 25, 2010·Radiology·Kakuya KitagawaAlbert C Lardo
Sep 24, 2011·AJR. American Journal of Roentgenology·Richard T GeorgeJoao A C Lima
Dec 7, 2011·The International Journal of Cardiovascular Imaging·J Tobias KühlKlaus Fuglsang Kofoed
Dec 8, 2011·Journal of Cardiovascular Computed Tomography·Vishal C MehraRichard T George
Aug 14, 2012·Circulation. Cardiovascular Imaging·Rodrigo J CerciJoao A C Lima
Apr 3, 2013·Journal of Cardiovascular Computed Tomography·Christina ByrneKlaus Fuglsang Kofoed
Nov 21, 2013·European Heart Journal·Carlos E RochitteJoao A C Lima
Dec 25, 2013·European Heart Journal·Filippo CreaCathleen Noel Bairey Merz
Nov 8, 2014·European Heart Journal Cardiovascular Imaging·Kheng-Thye HoQuek-Wei Yong
Citations
Jul 1, 2016·Cardiovascular Drugs and Therapy·Peter OngUdo Sechtem
Apr 9, 2017·Circulation. Cardiovascular Imaging·Alexia RossiFrancesca Pugliese
Aug 11, 2017·Circulation. Cardiovascular Imaging·Attila Feher, Albert J Sinusas
Nov 21, 2019·Radiology·Joanne D SchuijfJoão A C Lima
Feb 26, 2020·Nature Reviews. Cardiology·Marc DeweyUNKNOWN Quantitative Cardiac Imaging Study Group
Aug 19, 2020·European Radiology·Yan YiYi-Ning Wang
Nov 5, 2019·The International Journal of Cardiovascular Imaging·Daria Frestad BechsgaardJens Dahlgaard Hove
Oct 27, 2017·Current Cardiology Reports·Klaus F KofoedJesper J Linde
Oct 3, 2018·Clinical Physiology and Functional Imaging·Daria Frestad BechsgaardJens Dahlgaard Hove
Sep 10, 2020·Ultrasound in Medicine & Biology·Yuting LiuWei Jiang
May 1, 2021·Journal of Clinical Medicine·Elisabetta TonetGianluca Campo
Aug 14, 2021·Journal of the American College of Cardiology·Patrick W SerruysYoshinobu Onuma
Nov 6, 2021·European Heart Journal Cardiovascular Imaging·Thomas H MarwickIvan Stankovic