Endocardially Derived Macrophages Are Essential for Valvular Remodeling.

Developmental Cell
Ayako ShigetaAtsushi Nakano

Abstract

During mammalian embryogenesis, de novo hematopoiesis occurs transiently in multiple anatomical sites including the yolk sac, dorsal aorta, and heart tube. A long-unanswered question is whether these local transient hematopoietic mechanisms are essential for embryonic growth. Here, we show that endocardial hematopoiesis is critical for cardiac valve remodeling as a source of tissue macrophages. Colony formation assay from explanted heart tubes and genetic lineage tracing with the endocardial specific Nfatc1-Cre mouse revealed that hemogenic endocardium is a de novo source of tissue macrophages in the endocardial cushion, the primordium of the cardiac valves. Surface marker characterization, gene expression profiling, and ex vivo phagocytosis assay revealed that the endocardially derived cardiac tissue macrophages play a phagocytic and antigen presenting role. Indeed, genetic ablation of endocardially derived macrophages caused severe valve malformation. Together, these data suggest that transient hemogenic activity in the endocardium is indispensable for the valvular tissue remodeling in the heart.

Citations

Jul 6, 2020·Development·Anna O'Donnell, Katherine E Yutzey
Jun 21, 2020·Development·Karin D PrummelChristian Mosimann
Mar 15, 2020·Cardiovascular Research·Andrew J KimKatherine E Yutzey
Sep 30, 2020·Journal of Cardiovascular Development and Disease·Deborah J HendersonBill Chaudhry
May 2, 2020·Journal of the American College of Cardiology·Gonzalo Del Monte-NietoJason C Kovacic
Dec 8, 2020·Frontiers in Cell and Developmental Biology·Adam M HeckBrandon Hadland
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Wen Hao NeoGeorges Lacaud
Mar 13, 2021·Frontiers in Cell and Developmental Biology·Elvira Mass, Rebecca Gentek
Apr 15, 2021·Biomedical Journal·Serge A van de Pavert
Jun 6, 2021·Tissue Engineering. Part B, Reviews·Meenakshi SukuMichael G Monaghan
Jun 21, 2021·Current Opinion in Cell Biology·Felix GunawanDidier Y R Stainier
Aug 14, 2021·Heart Failure Reviews·Aneta MoskalikAnna Ratajska

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