Endocervical miRNA Expression Profiles in Women Positive for Chlamydia trachomatis with Clinical Signs and/or Symptoms Are Distinct from Those in Women Positive for Chlamydia trachomatis without Signs and Symptoms.

Infection and Immunity
Teresa A BatteigerLaxmi Yeruva

Abstract

Chlamydia trachomatis is the leading cause of sexually transmitted infections that may progress to pelvic inflammatory disease and infertility. No effective vaccine exists for Chlamydia, nor are there biomarkers available that readily predict disease progression. In this cross-sectional pilot study, we recruited symptomatic and asymptomatic women with C. trachomatis (CT) infection and asymptomatic, uninfected control women from an urban sexually transmitted disease clinic to determine if there were differences in microRNA (miRNA) expression. Infected women with signs and/or symptoms (CTSS) have distinct miRNA profiles compared to asymptomatic infected women (CTNS). In the CTSS group, miR-142 and -147 showed 2.2- to 6.9-fold increases in expression. In the CTNS group, miR-449c, -6779, -519d, -449a, and -2467 showed 3.9- to 9.0-fold increases in expression. In the CTNS group, cyclins and cell cycle regulation and IL-17 pathways were likely downregulated, while the same signaling pathways were upregulated in the CTSS group. In addition, in the CTSS group, additional inflammatory pathways associated with TNFR1 and IL-8 appear to be upregulated. The miRNA expression patterns differ between CT-infected symptomatic and asymptomatic wo...Continue Reading

References

Nov 1, 1987·Fertility and Sterility·G AnestadK Dalaker
Dec 1, 1985·The Journal of Infectious Diseases·R C BrunhamR W Peeling
Aug 17, 1999·Sexually Transmitted Infections·C R Cohen, R C Brunham
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael P GantierBryan R G Williams
Jun 6, 2012·RNA Biology·Ana EulalioJörg Vogel
Mar 22, 2013·PLoS Neglected Tropical Diseases·Tamsyn DerrickMartin J Holland
Nov 2, 2016·Infection and Immunity·Laxmi YeruvaRoger G Rank
Nov 1, 2017·Infection and Immunity·Joseph U IgietsemeCarolyn M Black
Mar 14, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaojing ZhengToni Darville
Feb 1, 2019·Nature·Thomas WohlfahrtAndreas Ramming

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Citations

Nov 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jinrong BaiXianli Meng
Mar 9, 2021·Expert Review of Vaccines·Luis M de la MazaSukumar Pal

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