Abstract
Objective. Anorexia nervosa is a condition of reduced hemodynamic load, characterized by varying degrees of cardiac remodelling, only in part related to reduced body mass; the mechanism for such variability, as well as its clinical significance, remains unknown. Aim of the study was to assess the possible influence of a great number of clinical, biochemical, and endocrine factors on cardiovascular parameters in restrictive anorexia nervosa. Method. Twenty-five female patients hospitalized for restrictive anorexia nervosa underwent extensive cardiovascular, clinical, and biochemical evaluation. Results. Height-adjusted and cardiac workload-matched left ventricular mass was significantly related to several endocrine parameters, blood pressure, and vasoreactivity. On multivariate analysis, IGF/GH ratio and systolic blood pressure were the only independent predictors of height-adjusted ventricular mass (adj-R(2) = 0.585; P = 0.001); when matching for cardiac workload, left ventricular mass was independently predicted only by GH and FT3 levels. All effects were independent of patient's weight and BMI. Conclusions. Indices of endocrine impairment seem to be the most relevant determinants of left ventricular hypotrophy in anorectic pa...Continue Reading
References
Nov 1, 1992·Journal of the American College of Cardiology·G de SimoneM H Alderman
Nov 1, 1985·Circulation·M G St John SuttonN Reichek
Mar 1, 1994·British Heart Journal·G de SimoneF Contaldo
Apr 30, 1999·Journal of Psychiatric Research·R K StøvingC Hagen
Apr 8, 2000·Journal of Child and Adolescent Psychopharmacology·K HillM Maloney
Apr 24, 2001·European Child & Adolescent Psychiatry·J FrölichU Lehmkuhl
Jan 15, 2002·Journal of the American College of Cardiology·Mary C CorrettiUNKNOWN International Brachial Artery Reactivity Task Force
Jan 24, 2003·The American Journal of Clinical Nutrition·Carmela RomanoGiovanni de Simone
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Steven GrinspoonAnne Klibanski
Jun 24, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·Lluís MontJosep Brugada
Nov 3, 2004·The American Journal of Cardiology·Edward Louis MelansonPhilip Sydney Mehler
Dec 27, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Roberto M LangUNKNOWN European Association of Echocardiography
Mar 27, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Mario PetrettaDomenico Bonaduce
Jan 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Fotios C PapadopoulosLisa Ekselius
Jun 16, 2009·Bone·Madhusmita MisraAnne Klibanski
Mar 23, 2010·The Journal of Clinical Endocrinology and Metabolism·Bruno EstourBogdan Galusca
Aug 4, 2010·Archives of Pediatrics & Adolescent Medicine·Amy D DiVastaMark E Alexander
Citations
Dec 30, 2015·The International Journal of Eating Disorders·Katherine V SachsMori J Krantz
May 19, 2012·Current Opinion in Endocrinology, Diabetes, and Obesity·Atil Y Kargi, George R Merriam
Oct 24, 2017·Eating and Weight Disorders : EWD·Lucia BilleciMaria Aurora Morales
Nov 10, 2013·PloS One·Shubo JinWenyi Zhang
Sep 3, 2018·Eating and Weight Disorders : EWD·Stefano GiovinazzoC Brunelli