PMID: 2681969Sep 1, 1989Paper

Endocrine and metabolic abnormalities following kidney transplantation

Klinische Wochenschrift
W H HörlH Wilms

Abstract

Various endocrine and metabolic disturbances associated with long standing uremia persist after kidney transplantation or arise from the use of immunosuppressive drugs. Hyperlipidemia for long time being implicated as the cause of corticosteroids is also observed in renal transplant recipients treated with cyclosporin A monotherapy. After conversion from cyclosporin to azathioprine serum cholesterol and triglyceride concentration fall, and elevation of LDL-cholesterol may also be reversed. There is a tendency for higher HDL-cholesterol in azathioprine and prednisolone treated transplant patients. Those patients who are at risk for clinically significant cholesterol elevations can be predicted by their pretransplant lipid levels, specifically the LDL-fraction. Risk-benefit ratio of conversion and of treatment with lipid-lowering drugs, especially with lovastatin, should be carefully examined, also in view of glucose intolerance. Higher incidence of diabetes mellitus requiring insulin therapy in cyclosporin treated transplant recipients has been reported. Cyclosporin may cause toxic effects on pancreatic beta-cells resulting in inhibition of insulin secretion. High doses of cyclosporin induce inhibition of glycogen synthesis in r...Continue Reading

References

Mar 15, 1975·Lancet·J E BeaumontR R Siegel
Jun 23, 1977·The New England Journal of Medicine·J D Bagdade, J J Albers
Dec 22, 1977·The New England Journal of Medicine·R MordasiniH Greten
Apr 1, 1978·The American Journal of Medicine·L S IbelsR Weil
Jun 1, 1978·Atherosclerosis·L K AbbottJ B Somer
Apr 7, 1979·British Medical Journal·E SavdieL A Simons
Jan 1, 1978·Nephron·C PonticelliM Cecchettin
May 1, 1979·Southern Medical Journal·N D VaziriD C Martin
Oct 1, 1979·Annals of Internal Medicine·D C CattranS A Fenton
Nov 1, 1976·Journal of Steroid Biochemistry·D EvainJ M Saez
Jul 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N YoshimuraT Oka
Jan 1, 1989·American Journal of Nephrology·A BenigniG Remuzzi
Mar 1, 1989·Klinische Wochenschrift·H SchmidtW Schoeppe
Apr 1, 1989·Transplant International : Official Journal of the European Society for Organ Transplantation·W RiegelW H Hörl
Jan 1, 1988·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A E RaineP J Morris
Dec 1, 1988·Transplantation·S C SikkaJ Rajfer
Feb 19, 1988·Deutsche medizinische Wochenschrift·D J ZiegenhagenC A Baldamus
Jun 1, 1988·Transplantation·P J GarvinJ Staggenborg
Jul 8, 1988·JAMA : the Journal of the American Medical Association·C L CorpierJ B Young
May 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·T Cundy, J A Kanis
Jul 1, 1987·Transplantation·R van SchilfgaardeA J Moolenaar
Apr 1, 1988·Transplantation·S C SikkaJ Rajfer
Jan 1, 1986·Transplantation·H J HahnR Warzock

Citations

May 1, 1990·Transplant International : Official Journal of the European Society for Organ Transplantation·W RiegelW H Hörl
Feb 9, 2000·Pharmacology & Therapeutics·A CorsiniF Bernini
Feb 23, 1999·Kidney International·M FödingerG Sunder-Plassmann
Jan 24, 2008·Transplantation·Yves F C VanrenterghemC Ponticelli
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bengt FellströmALERT Study Group
Sep 13, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Camila SardenbergMiguel Cendoroglo
Dec 1, 1996·Journal of Transplant Coordination : Official Publication of the North American Transplant Coordinators Organization (NATCO)·S L Smith

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