Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS)

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Lan WeiJiang Gu

Abstract

It is known that severe acute respiratory syndrome (SARS), a severe infectious illness, which caused an epidemic in Asia in 2003, has extensive and complex effects on human organ systems. It has been reported that the serum levels of prolactin (PRL), follicle stimulating hormone (FSH), and luteinizing hormone (LH) of SARS patients are significantly higher than those of control groups, while estradiol (E2), pregnancy hormone (P), and thyroid stimulating hormone (TSH) are considerably lower than those of normal controls. This phenomenon suggests that the adenohypophyseal endocrine cells in SARS patients may be damaged. However, up to now there has been no direct histological investigation on the endocrine cells of patients' pituitary. Here we investigated the endocrine cells in the adenohypophysis obtained from autopsies of 5 SARS patients. The immunohistochemistry and quantitative image results showed that compared with control cases, both the number of positive cells and the staining intensity of immunoreactivity for growth hormone, TSH, and adrenocorticotrophic hormone in these cells were remarkably decreased, while that of PRL, FSH, and LH were significantly increased in all SARS cases studied. These findings indicated that a...Continue Reading

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Citations

Feb 14, 2020·Journal of Medical Virology·Lei Zhang, Yunhui Liu
Jun 13, 2020·Postgraduate Medical Journal·Shubham Agarwal, Sanjeev Kumar Agarwal
Jul 1, 2020·Thyroid : Official Journal of the American Thyroid Association·Min ChenWeiwei Xu
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Feb 6, 2021·Endocrinology·Wenjie ChenJianyong Lei
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