Endocrine cells producing peptide hormones in the intestine of Nile tilapia: distribution and effects of feeding and fasting on the cell density

Fish Physiology and Biochemistry
Raquel Tatiane PereiraPriscila Vieira Rosa

Abstract

Endocrine cells (ECs) act as a luminal surveillance system responding to either the presence or absence of food in the gut through the secretion of peptide hormones. The aim of this study was to analyze the effects of feeding and fasting on the EC peptide-specific distribution along the intestine of Nile tilapia. We assessed the density of ECs producing gastrin (GAS), cholecystokinin-8 (CCK-8), neuropeptide Y (NPY), and calcitonin gene-related peptide (CGRP) in nine segments of the intestine using immunohistochemistry. Our results show that ECs immunoreactive to CCK-8, GAS, NPY, and CGRP can be found along all the intestinal segments sampled, from the midgut to hindgut, although differences in their distribution along the gut were observed. Regarding nutrient status, we found that the anterior segments of the midgut seem to be the main site responding to luminal changes in Nile tilapia. The NPY+ and CGRP+ EC densities increased in the fasted group, while the amount of CCK-8+ ECs were higher in the fed group. No effects of fasting or feeding were found in the GAS+ EC densities. Changes in ECs density were found only at the anterior segments of the intestine which may be due to the correlation between vagus nerve anatomy, EC loca...Continue Reading

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Citations

Jun 20, 2020·Anais Da Academia Brasileira De Ciências·Carlos E BarriosDavid R HernÁndez
Dec 15, 2020·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Neda GilannejadManuel Yúfera
Jun 5, 2021·Journal of Fish Biology·Angélica P C AlvesPriscila V Rosa

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