Endocrine consequences in young adult survivors of childhood cancer treatment

Annales d'endocrinologie
C LeroyR Desailloud

Abstract

Endocrine complications (particularly gonadal, hypothalamic-pituitary and metabolic) of childhood cancer treatments are common in young adults. Gonadal damage may be the result of chemotherapy or radiotherapy. Fertility preservation must be systematically proposed before initiation of gonadotoxic treatment if only the child is eligible. Hypothalamic-pituitary deficiency is common after brain or total-body irradiation, the somatotropic axis is the most sensitive to irradiation. Pituitary deficiency screening must be repeated since this endocrine consequence can occur many years after treatment. Hormone replacement must be prudent particularly in case of treatment with growth hormone or steroids. Metabolic syndrome, diabetes and cardiovascular damage resulting from cancer treatments contribute to the increase of morbidity and mortality in this population and should be screened routinely even if the patient is asymptomatic. The multidisciplinary management of these adults must be organized and the role of the endocrinologist is now well established.

References

Jan 1, 1989·The Journal of Endocrinology·S M ShaletG Read
Jan 1, 1986·The American Journal of Pediatric Hematology/oncology·P Zee, C H Chen
Mar 7, 1998·Bone Marrow Transplantation·E ThibaudR Brauner
Jul 6, 2000·Medical and Pediatric Oncology·T RelanderM Willén
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·M SchmiegelowJ Müller
Apr 7, 2005·The Lancet Oncology·W Hamish B WallaceD Stewart Irvine
Feb 24, 2006·The Journal of Clinical Endocrinology and Metabolism·Wassim ChemaitillyCharles A Sklar
Jan 15, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Roberto Bogarin, Paul Steinbok
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel M GreenLeslie L Robison
Oct 1, 2009·The Journal of Clinical Endocrinology and Metabolism·Patrik RomeriusAleksander Giwercman
Feb 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Markhaba TukenovaFlorent de Vathaire
Feb 16, 2010·The Lancet Oncology·Esther C de HaasJourik A Gietema
May 11, 2010·Endocrine-related Cancer·Wassim Chemaitilly, Charles A Sklar
Apr 12, 2011·Bone Marrow Transplantation·A Borgmann-StaudtG Strauss
Apr 15, 2011·Human Reproduction·K TrompL C M Kremer
Sep 17, 2011·The Journal of Pediatrics·Julia SteinbergerK Scott Baker
May 24, 2012·Obstetrics and Gynecology International·Shivany GnaneswaranRichard J Cohn
Jan 30, 2013·European Journal of Endocrinology·Whitney W WoodmanseeUNKNOWN GeNeSIS and HypoCCS International Advisory Boards
Jun 13, 2013·JAMA : the Journal of the American Medical Association·Melissa M HudsonLeslie L Robison
Oct 30, 2013·Nature Reviews. Endocrinology·Jacques Donnez, Marie-Madeleine Dolmans
Mar 13, 2014·International Journal of Radiation Oncology, Biology, Physics·Theodore GirinskyJean-François Paul
Mar 19, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory T ArmstrongKevin C Oeffinger
Jul 30, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Zhi-Feng Wang, Hong-Lin Chen
Aug 27, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frederika A van NimwegenFlora E van Leeuwen
Oct 8, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric J ChowYutaka Yasui
Dec 3, 2014·International Journal of Radiation Oncology, Biology, Physics·Helena J van der PalElvira C van Dalen
Jan 7, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wassim ChemaitillyCharles A Sklar
Jan 15, 2015·Annual Review of Medicine·Steven E LipshultzStephen E Sallan

❮ Previous
Next ❯

Citations

Jun 15, 2015·Annales d'endocrinologie·Philippe ChansonUNKNOWN French Endocrinology Society non-functioning pituitary adenoma work-group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Related Papers

Pediatric Endocrinology Reviews : PER
Sogol Mostoufi-Moab, Adda Grimberg
Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
Mitchell E Geffner
© 2022 Meta ULC. All rights reserved