Endocrine controls of primary adult human stem cell biology: thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro

European Journal of Cell Biology
S TiedeR Paus

Abstract

Here we demonstrate that physiological concentrations of the thyroid hormones T3 and T4 enhance the KERATIN 15 promoter activity and expression in epithelial stem cells of adult human scalp hair follicles in situ and in vitro. Additionally, T3 and T4 stimulate expression of the immuno-inhibitory surface molecule CD200. Subsequently, T3 and T4 induce apoptosis and differentiation and inhibit clonal growth of these progenitor cells in vitro. These data suggest that human hair follicle bulge-derived epithelial stem cells underlie profound, previously unknown hormonal regulation by thyroid hormones, and show that primary human keratin 15-GFP+ progenitor cells can be exploited to further elucidate fundamental endocrine controls of human epithelial stem cells.

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Citations

Nov 27, 2010·Pigment Cell & Melanoma Research·Ralf Paus
Mar 8, 2014·Cellular and Molecular Life Sciences : CMLS·Maria SirakovMichelina Plateroti
Sep 14, 2012·The Journal of Investigative Dermatology·Jiang Chen, Dennis R Roop
Mar 26, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Talveen S PurbaRalf Paus
Apr 10, 2012·Biochimica Et Biophysica Acta·Angel Pascual, Ana Aranda
Feb 7, 2015·Molecular Biology of the Cell·Constanza Contreras-JuradoAna Aranda
Jul 30, 2014·Trends in Molecular Medicine·Ralf PausBogi Andersen
Apr 26, 2018·Experimental Dermatology·Michael P Philpott
May 23, 2013·Endocrine Reviews·J BowersB A Demeneix
Sep 24, 2020·Biological Reviews of the Cambridge Philosophical Society·James D B O'SullivanRalf Paus
Jun 11, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·V KantiU Blume-Peytavi
Jun 14, 2012·International Journal of Molecular Medicine·Naoki NanashimaToshiya Nakamura
Aug 19, 2015·Experimental Dermatology·Ewan A LanganRalf Paus
May 11, 2018·Thyroid : Official Journal of the American Thyroid Association·Lidia Ruiz-LlorenteAna Aranda
Jul 16, 2021·The Journal of Dermatology·Waroonphan LeecharoenKanokvalai Kulthanan

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