Endocrine disrupting chemicals and COVID-19 relationships: A computational systems biology approach.

Environment International
Qier WuKarine Audouze

Abstract

Patients at high risk of severe forms of COVID-19 frequently suffer from chronic diseases, but other risk factors may also play a role. Environmental stressors, such as endocrine disrupting chemicals (EDCs), can contribute to certain chronic diseases and might aggravate the course of COVID-19. To explore putative links between EDCs and COVID-19 severity, an integrative systems biology approach was constructed and applied. As a first step, relevant data sets were compiled from major data sources. Biological associations of major EDCs to proteins were extracted from the CompTox database. Associations between proteins and diseases known as important COVID-19 comorbidities were obtained from the GeneCards and DisGeNET databases. Based on these data, we developed a tripartite network (EDCs-proteins-diseases) and used it to identify proteins overlapping between the EDCs and the diseases. Signaling pathways for common proteins were then investigated by over-representation analysis. We found several statistically significant pathways that may be dysregulated by EDCs and that may also be involved in COVID-19 severity. The Th17 and the AGE/RAGE signaling pathways were particularly promising. Pathways were identified as possible targets o...Continue Reading

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Citations

Jan 1, 2021·PloS One·Philippe GrandjeanKåre Mølbak
May 1, 2021·International Journal of Molecular Sciences·Elikanah Olusayo AdegokeMyung-Geol Pang

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Software Mentioned

Reactome
DisGeNet
GeneCards
Ensembl
CompTox
Panther

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