Endocrine-disrupting chemicals and male reproductive health.

Reproductive Medicine and Biology
Aditi SharmaSuks Minhas

Abstract

A number of different types of endocrine-disrupting chemicals (EDCs) including bisphenol A, phthalates, pesticides, and other environmental chemicals have been shown to adversely impact upon male reproductive health. Understanding the potential effects of EDCs on male reproductive health may enable the development of novel treatments and early prevention of the effects of EDCs on male infertility and their potential long-term sequelae. This review critically evaluates the research performed in this area and explores potential harmful effects of EDCs in animals and humans, including the possibility of trans-generational transmission. A literature review was conducted using electronic databases using the following terms: 'endocrine disrupt*' OR 'endocrine disruptors' OR 'endocrine disruptor chemicals' OR 'EDC' AND 'sperm*' OR 'spermatozoa' OR 'spermatozoon' OR 'male reproductive health' OR' male fertility'. Several studies have shown that EDCs have a variety of pathophysiological effects. These include failure of spermatogenesis, embryonic development, the association with testicular cancer, and long-term metabolic effects. Several studies observe correlations between chemical doses and at least one sperm parameter; however, such...Continue Reading

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Citations

Dec 10, 2020·The Journal of Clinical Endocrinology and Metabolism·Aditi SharmaChanna N Jayasena
Dec 16, 2020·Scientific Reports·Ricardo P Bertolla
Feb 10, 2021·International Journal of Environmental Research and Public Health·Saira AmirAristidis Tsatsakis
Mar 7, 2021·International Journal of Environmental Research and Public Health·Mar Requena-MullorRaquel Alarcon-Rodriguez
Feb 15, 2021·Prenatal Diagnosis·Ayana L Henderson, Monica P Colaiácovo
Mar 7, 2021·Antioxidants·Joana SantiagoMargarida Fardilha
Mar 12, 2021·Molecular Human Reproduction·Julieta B GrossoSilvana V Spinelli

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