Endocrine-disrupting effects of bisphenols on urological cancers.

Environmental Research
Eve PellerinMartin Pelletier

Abstract

Bisphenols are endocrine-disrupting chemicals found in a broad range of products that can modulate hormonal signalling pathways and various other biological functions. These compounds can bind steroid receptors, e.g. estrogen and androgen receptors, expressed by numerous cells and tissues, including the prostate and the bladder, with the potential to alter their homeostasis and normal physiological functions. In the past years, exposure to bisphenols was linked to cancer progression and metastasis. As such, recent pieces of evidence suggest that endocrine-disrupting chemicals can lead to the development of prostate cancer. Moreover, bisphenols are found in the urine of the wide majority of the population. They could potentially affect the bladder's normal physiology and cancer development, even if the bladder is not recognized as a hormone-sensitive tissue. This review will focus on prostate and bladder malignancies, two urological cancers that share standard carcinogenic processes. The description of the underlying mechanisms involved in cell toxicity, and the possible roles of bisphenols in the development of prostate and bladder cancer, could help establish the putative roles of bisphenols on public health.

References

May 25, 1995·The New England Journal of Medicine·M E TaplinS P Balk
Oct 1, 1993·Environmental Health Perspectives·T ColbornA M Soto
Dec 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·C A BerrevoetsE Mulder
Oct 29, 2002·Reproductive Toxicology·Hideto YamadaSeiichiro Fujimoto
Apr 15, 2004·Endocrine Reviews·Cynthia A Heinlein, Chawnshang Chang
Jun 1, 2004·The Oncologist·Mohammad H Rashid, Uzair B Chaudhary
Aug 12, 2004·International Journal of Cancer. Journal International Du Cancer·Kjersti BakkenEiliv Lund
Oct 14, 2004·Clinical Prostate Cancer·Yoshihisa KinoshitaGabriel P Haas
Mar 17, 2005·World Journal of Urology·Alan SoColleen Nelson
Jul 21, 2005·International Journal of Cancer. Journal International Du Cancer·Meaghan L DouglasDavid L Nicol
Apr 5, 2007·Journal of the National Cancer Institute·Hiroshi MiyamotoChawnshang Chang
Dec 7, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·William A RickeGail P Risbridger
Feb 19, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Frederick S vom SaalRobert T Zoeller
Aug 13, 2011·Environmental Health Perspectives·David MelzerTamara Galloway
Oct 7, 2011·The Science of the Total Environment·Elisa V BanderaHelmut Zarbl
Feb 1, 2012·International Journal of Cancer. Journal International Du Cancer·E Christina PerssonKatherine A McGlynn
Aug 29, 2012·Cancer Research·Shibu ThomasDan Theodorescu
Feb 12, 2013·World Journal of Urology·Georgios Gakis, Arnulf Stenzl
Mar 1, 2013·Endocrine-related Cancer·Yi LiHiroshi Miyamoto
Jun 5, 2013·Translational Oncology·Suraj Konnath GeorgeCarolyn L Smith
Sep 3, 2013·Reproductive Toxicology·Johanna R Rochester
Feb 4, 2014·Environmental Health Perspectives·Caren WeinhouseDana C Dolinoy
Mar 7, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·David J AndersonDiana G Wilkins
Mar 8, 2014·World Journal of Surgical Oncology·Baoming RenSongdi Wu

❮ Previous
Next ❯

Citations

Aug 7, 2021·Bioengineering·Christophe CaneparoStéphane Bolduc

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.