PMID: 6538094Feb 1, 1984Paper

Endocrine effects of danazol in the treatment of endometriosis

British Journal of Obstetrics and Gynaecology
J R BevanS L Jeffcoate

Abstract

The effects of danazol therapy on circulating gonadotrophins, oestradiol and sex hormone-binding globulin (SHBG) binding capacity have been studied in eight patients with endometriosis. There was a significant rise in luteinizing hormone (LH) in the first week of treatment with a fall in oestradiol levels. There was a marked fall in SHBG in the first week which continued up to 4 weeks. It is concluded that danazol is not 'anti-gonadotrophic' as frequently claimed and that its therapeutic actions, side effects and the endocrine changes could be explained by an effect on SHBG production. The rationale of its use in other conditions requires reconsideration.

References

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Citations

Feb 25, 1991·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G B CandianiP E Fontana
Oct 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·J M GledhillG P Vinson
Sep 11, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S Duffy
Oct 1, 1986·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J GuothB Zsolnai
Sep 1, 1985·European Journal of Cancer & Clinical Oncology·M DowsettS L Jeffcoate
Jan 1, 1986·Annals of the New York Academy of Sciences·L DogliottiA Angeli
Nov 1, 1989·The Australian & New Zealand Journal of Obstetrics & Gynaecology·I S FraserR Markham
May 1, 1986·British Journal of Obstetrics and Gynaecology·R I McLachlanH G Burger
Sep 12, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Vincenzo De LeoFelice Petraglia

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