PMID: 7542400Mar 1, 1995Paper

Endocrine environment of benign prostatic hyperplasia: prostate size and volume are correlated with serum estrogen concentration

Scandinavian Journal of Urology and Nephrology
K SuzukiS Honma

Abstract

Estrogen plays an important role in the development of benign prostatic hyperplasia (BPH), as has been shown in both experimental and clinical studies. T determine the endocrine environment of BPH, serum total testosterone (Total-T), free testosterone (Free-T), and estradiol (E2) conceptions were measured, and the relationship between these levels and prostate size and volume was analyzed. Blood samples were collected from subjects who attended the mass screening for prostate disease performed by our institute. No significant correlations were found between Total-T levels, Free-T levels, and prostate size, as determined by digital rectal examination. However, E2 levels and the ratios for E2 levels and the ratios for E2/Total-T and E2/Free-T were significantly correlated with prostate size. To confirm these relationships, prostate volume was calculated from transrectal ultrasonographic images. E2 levels and these two ratios were, indeed, highly correlated with prostate volume. These results suggest that an estrogen-dominant environment plays an important role in the development of BPH.

References

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Citations

Nov 14, 2002·The Prostate·Michael A JosephDavid Schottenfeld
Oct 1, 2008·Prostate Cancer and Prostatic Diseases·J HammarstenD Mellström
Apr 7, 2004·The Tohoku Journal of Experimental Medicine·Yoshihiro OnoHidetoshi Yamanaka
Jan 1, 2011·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Chukwunonso E C C Ejike, Lawrence U S Ezeanyika
Sep 12, 2006·The Medical Clinics of North America·Matthew T HarenJohn E Morley
Oct 9, 1999·Scandinavian Journal of Urology and Nephrology·A BødkerK E Andersson
Jul 19, 2018·American Journal of Physiology. Renal Physiology·Tristan M NicholsonWilliam A Ricke
Aug 12, 2004·The Prostate·Rosebud O RobertsSteven J Jacobsen
Nov 19, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura O'HaraLee B Smith
Jan 28, 2005·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·F Comhaire, A Mahmoud
Jan 21, 2011·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Chun-Hou LiaoHong-Jeng Yu
Aug 21, 2018·Frontiers in Endocrinology·Zhuo LiXinhua Zhang
Feb 24, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yuichiro TanakaRajvir Dahiya

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