Endocrine function is altered in chronic migraine patients with medication-overuse

Headache
Innocenzo RaineroLorenzo Pinessi

Abstract

To evaluate the effects of analgesic overuse on endocrine function in patients with chronic migraine and medication-overuse headache (CM-MOH). Chronic migraine is frequently associated with an overuse of symptomatic medications. Drugs currently used in acute migraine attacks are associated with several endocrine effects. At present, the endocrine effects of medication overuse in chronic migraine patients are unknown. Eighteen patients with CM-MOH, diagnosed according to the ICHD-II criteria, and 18 healthy controls received an intravenous administration of GHRH, hCRH, and TRH. Plasma concentrations of GH, TSH, ACTH, and cortisol were measured for a 90-minute period after administration of the specific releasing hormones. Hormonal basal concentrations were similar in both groups. GH response to GHRH was significantly reduced in patients with CM-MOH in comparison with controls. TRH induced a reduction of TSH concentrations only at the end of the test. After hCRH administration, ACTH and cortisol concentrations were significantly higher in cases than in controls. A significant correlation between duration of the disease and altered hormonal response was found. Our study shows that both corticotropic and somatotropic functions are ...Continue Reading

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Citations

Mar 12, 2009·The Neurologist·Michael J Marmura
Sep 4, 2010·Cephalalgia : an International Journal of Headache·B Lee PeterlinKathleen R Merikangas
Jan 12, 2016·Current Neurology and Neuroscience Reports·Shuhan Zhu, Michael J Marmura
Jun 6, 2009·Headache·Letizia Maria CupiniPaolo Calabresi
Sep 1, 2006·Headache·Francesca Romana Patacchioli, Paolo Martelletti
Feb 28, 2009·Headache·B Lee PeterlinSarah Meng
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Feb 19, 2011·The Journal of Headache and Pain·Anita TrauningerZoltán Pfund
May 1, 2013·Cephalalgia : an International Journal of Headache·Anne LepperStefan Evers
Apr 24, 2018·Cephalalgia : an International Journal of Headache·Elisa RubinoPaolo Limone
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