Endocrine heart after lung transplantation: increased brain natriuretic peptide is related to right ventricular function

Transplant International : Official Journal of the European Society for Organ Transplantation
Paola Goette-Di MarcoB Geny

Abstract

Brain natriuretic peptide (BNP) increases in proportion to the extent of right ventricular dysfunction in pulmonary hypertension and after heart transplantation. No data are available after lung transplantation. Clinical, biological, respiratory, echocardiographic characteristics and circulating BNP and its second messenger cyclic guanosine monophosphate (cGMP) were determined in thirty matched subjects (10 lung-, 10 heart-transplant recipients (Ltx, Htx) and 10 healthy controls). Eventual correlations between these parameters were investigated. Heart rate and pulmonary arterial blood pressure were slightly increased after transplantation. Creatinine clearance was decreased. Mean of forced expiratory volume in 1 s was 76.6 +/- 5.3% and vital capacity was 85.3 +/- 6.4% of the predicted values in Ltx. BNP was similarly increased in Ltx and Htx, as compared with control values (54.1 +/- 14.2 and 45.6 +/- 9.2 vs. 6.2 +/- 1.8 pg/ml, respectively). Significant relationships were observed between plasma BNP and cGMP values (r = 0.62; P < 0.05 and r = 0.75; P < 0.01, in Ltx and Htx) and between BNP and right ventricular fractional shortening and tricuspid E/Ea ratio in Ltx (r = -0.75 and r = 0.93; P < 0.01, respectively). BNP is increa...Continue Reading

References

Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·B GenyJ Lonsdorfer
Feb 25, 1998·The Journal of Thoracic and Cardiovascular Surgery·B GenyF Piquard
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·James R KlingerNicholas S Hill
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Peter A McCulloughUNKNOWN Breathing Not Properly Multinational Study Investigators
Aug 20, 2003·European Journal of Clinical Investigation·A CharlouxB Geny
Nov 25, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Isabel HervásAntonio Mateo
Mar 5, 2004·Journal of the American College of Cardiology·Hanno H LeuchteJürgen Behr
Jun 11, 2004·Zhonghua er ke za zhi. Chinese journal of pediatrics·Jian Liu, Xiao-ping Luo
Jul 21, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Miguel A Arnau-VivesMiguel Palencia
Oct 16, 2004·Chest·Lok Bin YapJohn Gerard Coghlan
Feb 5, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Roland KlingenbergThomas J Dengler
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Mar 10, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Stephane DoutreleauBernard Geny
Oct 9, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·L Martinez-DolzA Salvador
Nov 3, 2007·American Journal of Respiratory and Critical Care Medicine·Hiroaki ObataNoritoshi Nagaya
Dec 25, 2007·Journal of the American College of Cardiology·Lori B Daniels, Alan S Maisel
May 8, 2008·American Journal of Respiratory and Critical Care Medicine·Paul A Corris, Jason D Christie
Sep 4, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jason D ChristieMarshall I Hertz
Feb 12, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Claus NeurohrUNKNOWN Munich Lung Transplant Group
Jun 2, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Akihiro AoyamaToru Bando
Mar 1, 1993·The European Respiratory Journal·P H QuanjerJ C Yernault

❮ Previous
Next ❯

Citations

Dec 16, 2010·Frontiers in Neuroendocrinology·James C WaltonRandy J Nelson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved