Endocrine-Mediated Mechanisms of Metabolic Disruption and New Approaches to Examine the Public Health Threat

Frontiers in Endocrinology
Christopher D Kassotis, Heather M Stapleton

Abstract

Obesity and metabolic disorders are of great societal concern and generate substantial human health care costs globally. Interventions have resulted in only minimal impacts on disrupting this worsening health trend, increasing attention on putative environmental contributors. Exposure to numerous environmental contaminants have, over decades, been demonstrated to result in increased metabolic dysfunction and/or weight gain in cell and animal models, and in some cases, even in humans. There are numerous mechanisms through which environmental contaminants may contribute to metabolic dysfunction, though certain mechanisms, such as activation of the peroxisome proliferator activated receptor gamma or the retinoid x receptor, have received considerably more attention than less-studied mechanisms such as antagonism of the thyroid receptor, androgen receptor, or mitochondrial toxicity. As such, research on putative metabolic disruptors is growing rapidly, as is our understanding of molecular mechanisms underlying these effects. Concurrent with these advances, new research has evaluated current models of adipogenesis, and new models have been proposed. Only in the last several years have studies really begun to address complex mixtures...Continue Reading

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Citations

Sep 15, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Caleb E Finch, Alexander M Kulminski
Aug 14, 2020·International Journal of Environmental Health Research·Aylin BalcıBelma Kocer-Gumusel
Apr 30, 2020·International Journal of Molecular Sciences·Jenni KüblbeckAnna-Liisa Levonen
Aug 1, 2019·Cellular and Molecular Life Sciences : CMLS·Francesca RiuzziRosario Donato
Dec 19, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Samuel W CaitoMichael Aschner
Oct 21, 2020·Cells·Jenni KüblbeckPaavo Honkakoski
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Apr 19, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Iris Reina-PérezMariana F Fernández
Jan 27, 2022·Environmental Science & Technology·Johannes VölkerMartin Wagner

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