Endocrine Pancreas Development and Regeneration: Noncanonical Ideas From Neural Stem Cell Biology

Diabetes
Jimmy MasjkurAndreas Androutsellis-Theotokis

Abstract

Loss of insulin-producing pancreatic islet β-cells is a hallmark of type 1 diabetes. Several experimental paradigms demonstrate that these cells can, in principle, be regenerated from multiple endogenous sources using signaling pathways that are also used during pancreas development. A thorough understanding of these pathways will provide improved opportunities for therapeutic intervention. It is now appreciated that signaling pathways should not be seen as "on" or "off" but that the degree of activity may result in wildly different cellular outcomes. In addition to the degree of operation of a signaling pathway, noncanonical branches also play important roles. Thus, a pathway, once considered as "off" or "low" may actually be highly operational but may be using noncanonical branches. Such branches are only now revealing themselves as new tools to assay them are being generated. A formidable source of noncanonical signal transduction concepts is neural stem cells because these cells appear to have acquired unusual signaling interpretations to allow them to maintain their unique dual properties (self-renewal and multipotency). We discuss how such findings from the neural field can provide a blueprint for the identification of ne...Continue Reading

References

Nov 5, 1997·Nature Genetics·D A StoffersJ F Habener
Jun 17, 1998·Genes & Development·M HebrokD A Melton
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·S K Kim, D A Melton
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·F MirallesR Scharfmann
Sep 7, 1999·Nature·A ApelqvistH Edlund
Dec 30, 1999·Nature Genetics·J JensenO D Madsen
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·G GradwohlF Guillemot
Apr 25, 2000·Molecules and Cells·R KageyamaK Tomita
Jun 8, 2000·Mechanisms of Development·E LammertD A Melton
May 4, 2001·Diabetes·J C LeeM S German
Sep 5, 2002·Nature Reviews. Molecular Cell Biology·David E Levy, J E Darnell
Jan 28, 2003·Current Biology : CB·Marko E HorbJonathan M W Slack
Mar 6, 2003·Gene Expression Patterns : GEP·Natalia Schröder, Achim Gossler
Jun 20, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Oleg LioubinskiMaike Sander
Aug 15, 2003·Development·Hiroshi KawahiraMatthias Hebrok
Oct 1, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alan HartHelena Edlund
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·L Charles MurtaughDouglas A Melton
May 25, 2004·Nature Cell Biology·Sachiko KamakuraYukiko Gotoh
Mar 16, 2005·Developmental Biology·Hiroshi KawahiraMatthias Hebrok
Dec 3, 2005·The International Journal of Developmental Biology·Francisco MirallesRajiv L Joshi
Jun 20, 2006·Molecular and Cellular Biology·Céline SouilholMichel Cohen-Tannoudji
Jun 27, 2006·Nature·Andreas Androutsellis-TheotokisRonald D G McKay
Aug 11, 2006·Developmental Biology·Senta GeorgiaAnil Bhushan
Feb 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Philip A SeymourMaike Sander
Feb 16, 2007·Biochemical and Biophysical Research Communications·Andrew J BallFred Levine

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