PMID: 9192961May 1, 1997Paper

Endocrine profiles after radiotherapy in stage I seminoma: impact of two different radiation treatment modalities

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
H JoosL Rettenbacher

Abstract

In patients with stage I seminoma treated with elective lymph node irradiation, testicular scatter doses are often thought to be responsible for later disturbances in fertility. We studied the influence of radiation field extensions and testicular doses on hormonal function. FSH (follicle stimulating hormone) and LH (luteinizing hormone) were evaluated before radiotherapy (RT) and by serial analyses after treatment for 4 years. Twenty-three patients were irradiated by hockey stick fields with a mean dose of 31.9 Gy (+/-4.7 SD) and a mean scatter dose of 54 8 cGy (+/-16.6 SD). Twenty-one patients received limited RT to the paraaortic nodes with 28.1 Gy (+/-2.4 SD). The mean testicular dose was only 25 cGy (+/-7.8 SD). All patients had normal pre-treatment hormonal values. Six months after the end of RT, mean FSH values were significantly elevated in the hockey stick group (P = 0.032), returning to normal after 3 years. The increase in LH was also significant, but stayed within normal ranges. Limited RT resulted in a minimal, dose-dependent increase of FSH; no changes in LH were noted. In patients with a normal hormonal status after semicastration, FSH is a reliable monitor for transient radiation-induced effects. To avoid treatm...Continue Reading

References

Nov 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S D TinklerG R Kerr
Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
Jun 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P V HansenJ Hvolby
Feb 1, 1989·International Journal of Radiation Oncology, Biology, Physics·S D FossåO Kaalhus
Dec 1, 1982·Cancer·D BallM J Peckham
Nov 1, 1983·International Journal of Radiation Oncology, Biology, Physics·S NaderN A Samaan
Jan 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M A Izard
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H von der MaaseH Schultz
Sep 1, 1993·International Journal of Radiation Oncology, Biology, Physics·P R WardeA J Munro
Nov 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M NiewaldU Humke

❮ Previous
Next ❯

Citations

Dec 10, 1999·Seminars in Surgical Oncology·M F MilosevicP Warde
Jun 12, 2009·World Journal of Urology·Nathan Lawrentschuk, Neil Fleshner
Jul 3, 2013·Current Urology Reports·Daniel H Williams
Jun 14, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Johannes ClassenMichael Bamberg
Jul 7, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S BieriR Miralbell
Jun 29, 2001·International Journal of Radiation Oncology, Biology, Physics·F SedlmayerUNKNOWN Australian Uro-Oncology Group (AUO)
Dec 24, 2005·Oncology·F ChristophM Schrader
Feb 1, 2010·Therapeutic Advances in Urology·Daniel H Williams
Sep 5, 1998·The Urologic Clinics of North America·G D Grossfeld, E J Small
Jul 24, 2007·Critical Reviews in Oncology/hematology·R J GrollM A S Jewett
Nov 3, 2005·Journal of the National Cancer Institute·Marianne BrydøyOlav Dahl
Aug 11, 2006·Medical Physics·Michalis MazonakisNicholas Gourtsoyiannis
Aug 21, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H J SchmollUNKNOWN European Germ Cell Cancer Consensus Group
May 15, 2007·Acta Oncologica·Marianne BrydøyTrine Bjøro
Dec 22, 1999·International Journal of Cancer. Journal International Du Cancer·M DeSantisJ Pont
Mar 19, 2011·Acta Oncologica·Thomas ZilliDaniel Taussky
May 7, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·G Gruber, N Schwegler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Seminars in Reproductive Medicine
Ellen Goossens, Herman Tournaye
American Journal of Clinical Oncology
Jeffrey G NalesnikThomas A Buchholz
© 2021 Meta ULC. All rights reserved