Endocrine regulation of multichromatic color vision

Proceedings of the National Academy of Sciences of the United States of America
Robert D MackinDeborah L Stenkamp

Abstract

Vertebrate color vision requires spectrally selective opsin-based pigments, expressed in distinct cone photoreceptor populations. In primates and in fish, spectrally divergent opsin genes may reside in head-to-tail tandem arrays. Mechanisms underlying differential expression from such arrays have not been fully elucidated. Regulation of human red (LWS) vs. green (MWS) opsins is considered a stochastic event, whereby upstream enhancers associate randomly with promoters of the proximal or distal gene, and one of these associations becomes permanent. We demonstrate that, distinct from this stochastic model, the endocrine signal thyroid hormone (TH) regulates differential expression of the orthologous zebrafish lws1/lws2 array, and of the tandemly quadruplicated rh2-1/rh2-2/rh2-3/rh2-4 array. TH treatment caused dramatic, dose-dependent increases in abundance of lws1, the proximal member of the lws array, and reduced lws2 Fluorescent lws reporters permitted direct visualization of individual cones switching expression from lws2 to lws1 Athyroidism increased lws2 and reduced lws1, except within a small ventral domain of lws1 that was likely sustained by retinoic acid signaling. Changes in lws abundance and distribution in athyroid z...Continue Reading

References

Jun 17, 1988·Science·D VollrathR W Davis
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y WangJ Nathans
Apr 29, 2000·Progress in Retinal and Eye Research·S Yokoyama
Jan 3, 2001·Developmental Biology·A Perz-EdwardsE Linney
Nov 2, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Deborah L StenkampEmily E Shupe
Jul 27, 2005·Investigative Ophthalmology & Visual Science·Melanie R RobertsThomas A Reh
Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Antonio C Bianco, P Reed Larsen
Apr 12, 2006·Proceedings of the National Academy of Sciences of the United States of America·Melanie R RobertsThomas A Reh
Jul 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Taro TsujimuraShoji Kawamura
Nov 29, 2007·Zebrafish·Raymond E EngeszerDavid M Parichy
Oct 16, 2008·BMC Developmental Biology·Jeffrey M TrimarchiConstance L Cepko
Aug 18, 2009·The Journal of Experimental Biology·J C Raine, C W Hawryshyn
Jul 20, 1939·The Journal of General Physiology·G Wald
Aug 24, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kathlyn J Gan, Iñigo Novales Flamarique
Apr 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anika GlaschkeMartin Glösmann
Dec 1, 2009·Integrative and Comparative Biology·Christopher M Hofmann, Karen L Carleton
Sep 1, 2011·BMC Developmental Biology·Craig B StevensDeborah L Stenkamp
Mar 3, 2012·Zoological Science·Juhua ChangGuonian Zhu
May 5, 2012·Molecular Endocrinology·Douglas Forrest, Anand Swaroop
Aug 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sachihiro C SuzukiRachel O L Wong
Aug 30, 2014·Science·Sarah K McMenaminDavid M Parichy
Jul 17, 2015·Proceedings. Biological Sciences·Yohey OgawaYoshitaka Fukada
Nov 10, 2015·Current Biology : CB·Jennifer M EnrightJoseph C Corbo
Jan 24, 2016·Molecular and Cellular Endocrinology·Anne M HoubrechtsVeerle M Darras
Sep 22, 2017·Zebrafish·Sarah McMenaminWiliam James Cooper
Jun 26, 2018·Current Biology : CB·Maxime J Y ZimmermannTom Baden
Oct 13, 2018·Science·Kiara C EldredRobert J Johnston

❮ Previous
Next ❯

Citations

Jun 17, 2020·Proceedings of the National Academy of Sciences of the United States of America·Leo I VolkovJoseph C Corbo
Nov 3, 2020·The Journal of Comparative Neurology·Michael J CamerinoPeter G Fuerst
Feb 19, 2021·Pflügers Archiv : European journal of physiology·Jingjing Zang, Stephan C F Neuhauss
Mar 30, 2021·The Journal of Comparative Neurology·Iñigo Novales FlamariqueGoro Yoshizaki
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Susov DhakalDeborah L Stenkamp

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
confocal microscopy
transgenics
dissection
PCR
in vitro reverse transcription

Software Mentioned

ImageJ
Nikon Elements

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.