Endocrine role of stomach in appetite regulation in chronic kidney disease: about ghrelin and obestatin

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
Denise MafraD Fouque

Abstract

The stomach may play an important role in central feeding regulation because it produces two peptides, ghrelin and the recently identified obestatin. These peptide hormones exert opposite actions on weight regulation. Whereas ghrelin is orexigenic, obestatin seems to be anorexigenic. Studies on feeding regulation are of particular importance for patients with chronic kidney disease (CKD), because anorexia and weight loss are associated with wasting and increased morbidity and mortality. This review discusses recent information about ghrelin and obestatin and their potential role in CKD. In addition, it seems important to consider not only single values but also their ratios, because both compounds could be affected disharmoniously by CKD.

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Citations

Aug 16, 2011·Medical Hypotheses·J F SaldanhaD Mafra
Apr 5, 2011·Molecular and Cellular Endocrinology·Inge SeimLisa Chopin
Jan 5, 2011·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Yildiz Oner-IyidoganAydin Turkmen
Jan 28, 2014·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Natália BorgesDenise Mafra
Jan 25, 2018·European Journal of Clinical Nutrition·Anna KatkovIlia Beberashvili
Dec 24, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

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