Endocrine tumors of the pancreas: Ki-67 immunoreactivity on paraffin sections is an independent predictor for malignancy: a comparative study with proliferating-cell nuclear antigen and progesterone receptor protein immunostaining, mitotic index, and other clinicopathologic variables

Human Pathology
G PelosiGiuseppe Zamboni

Abstract

Prediction for malignancy of pancreatic endocrine tumors (PET) is often a formidable challenge for the pathologist. The authors evaluated the role of the proliferative activity and progesterone receptor protein (PgRP) in predicting prognosis and survival of PET. Twenty-three functioning (FT) and 31 nonfunctioning tumors (NFT) were evaluated for mitotic activity and immunostaining for Ki-67 antigen, proliferating cell nuclear antigen (PCNA), and progesterone receptor protein (PgRP) on paraffin sections. The results were expressed as a percentage (index) of immunoreactive or mitosing cells. All 54 cases showed immunostaining for Ki-67 and PCNA, and valuable mitotic index, whereas only a fraction of tumors (25 of 54 cases) exhibited PgRP expression. Ki-67 and PCNA indexes correlated strongly between themselves and to mitotic index, whereas an inverse relationship was observed between cell proliferation and PgRP status in both FT and NFT. Although univariate analysis showed that Ki-67, PCNA, mitotic and PgRP indexes, stage, immunoreactivity for hormones other than insulin, diameter, and nonfunctioning type of tumor were statistically correlated to survival, Cox's regression method let only Ki-67 index emerge as an independent predi...Continue Reading

References

Jan 15, 1990·Cancer·S VenkateshN A Samaan
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·C BordiC Betterle
Dec 1, 1990·Cancer·F Graeme-CookC Compton
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·C BordiT D'Adda
Apr 1, 1988·Pathology, Research and Practice·G Klöppel, P U Heitz
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·D R LohmannH Höfler

❮ Previous
Next ❯

Citations

Nov 18, 2011·World Journal of Surgery·Sara EkebladBritt Skogseid
Sep 13, 2006·Virchows Archiv : an International Journal of Pathology·G RindiUNKNOWN European Neuroendocrine Tumor Society (ENETS)
May 9, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David S Klimstra
Jul 29, 1998·Journal of Internal Medicine·P KomminothG Klöppel
May 13, 2005·Gut·J K RamageUNKNOWN UKNETwork for Neuroendocrine Tumours
Oct 13, 2004·Neuroendocrinology·G Rindi, G Klöppel
May 30, 2008·Endocrine-related Cancer·Thorvardur R HalfdanarsonGloria M Petersen
Aug 28, 2009·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·José Gaal, Ronald R de Krijger
Feb 9, 2016·Diagnostics·Emma Elizabeth IlettUlrich Knigge
Mar 21, 2012·American Journal of Clinical Pathology·Pamela P GoodellDouglas J Hartman
Jun 24, 2010·The Veterinary Journal·Floryne O BuishandJolle Kirpensteijn
Aug 19, 2015·Journal of Clinical Pathology·Nathaniel MellingAndreas Holger Marx
May 9, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R BettiniM Falconi
Dec 17, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Kaisa SalmenkiviJohanna Arola
May 22, 2004·Annals of the New York Academy of Sciences·Håkan AhlmanMichael Olausson
Nov 15, 2006·Annals of the New York Academy of Sciences·Håkan Ahlman
Jan 13, 2006·Clinical Endocrinology·Delphine VezzosiLouis Buscail
Oct 30, 2013·Asia-Pacific Journal of Clinical Oncology·Laeeq MalikDesmond Yip
Oct 19, 2011·Journal of Surgical Oncology·Christina L RolandRoderich E Schwarz
Aug 18, 2004·Pathology, Research and Practice·João Carlos das Neves PereiraVera Luiza Capelozzi
Sep 19, 2015·Virchows Archiv : an International Journal of Pathology·Annika BlankAurel Perren
Sep 27, 2005·Best Practice & Research. Clinical Gastroenterology·Andreas PascherPeter Neuhaus
May 23, 2003·The Korean Journal of Internal Medicine·Chang Hwa LeeKuk Hyun Song
Aug 10, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Andrea RuzzenenteCalogero Iacono
Oct 23, 2013·Seminars in Diagnostic Pathology·Zhaohai YangDavid S Klimstra
Jan 22, 2009·AJR. American Journal of Roentgenology·Roberto MalagòRoberto Pozzi Mucelli
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dik J KwekkeboomEric P Krenning
Jun 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven N HochwaldDavid S Klimstra
Apr 14, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G RindiV Villanacci
Mar 9, 2006·Virchows Archiv : an International Journal of Pathology·Yu TakahashiSetsuo Hirohashi
Jan 19, 2006·Virchows Archiv : an International Journal of Pathology·Y KapranG Klöppel
Jun 16, 2009·Internal Medicine·Yukiyoshi OkauchiIichiro Shimomura
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Edoardo MissiagliaAldo Scarpa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.