PMID: 9557921Apr 29, 1998Paper

Endocrinological abnormalities in angiotensinogen-gene knockout mice: studies of hormonal responses to dietary salt loading

Journal of Hypertension
S UmemuraM Ishii

Abstract

Physiological roles of the renin-angiotensin system in maintaining blood pressure and sodium-water balance in angiotensinogen gene-knockout mice were evaluated with special reference to endogenous pressor substances. Angiotensinogen-gene knockout mice and control mice were fed a 0.3 or 4% NaCl diet for 2 weeks. Systolic blood pressure and urinary excretions of electrolytes, creatinine, aldosterone, adrenaline, noradrenaline, dopamine and vasopressin were measured. About 60% of our angiotensinogen-gene knockout mice did not survive until weaning. These mice presented with hypotension and polyuria. Urinary excretion of aldosterone from such mice was significantly lower (not detected) than that from control mice (2.0+/-0.3 pg/mg creatinine). In contrast, urinary excretion of vasopressin from angiotensinogen-gene knockout mice (0.7+/-0.1 ng/mg creatinine) was greater than that from control mice (0.3+/-0.1 ng/mg creatinine), and those of adrenaline and of noradrenaline were similar for knockout and control mice. After salt loading (a 4% NaCl diet), angiotensinogen-gene knockout mice exhibited a significant increase in systolic blood pressure (from 68.3+/-2.9 to 95.9+/-5.9 mmHg), significant decreases in urinary excretions of adrenal...Continue Reading

References

Apr 1, 1976·The Journal of Clinical Endocrinology and Metabolism·G L Robertson, S Athar
Jun 7, 1991·Brain Research·M S King, A J Baertschi
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·H S KimO Smithies
Jun 9, 1997·Biochemical and Biophysical Research Communications·N NyuiM Ishii

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Citations

Apr 12, 2003·Clinical and Experimental Pharmacology & Physiology·Sharyn M FitzgeraldGöran Bergström
Jan 20, 2012·Kidney International·Jurgen Schnermann, Josephine P Briggs
Mar 19, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sarah A SapouckeyJustin L Grobe

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