PMID: 8591104Feb 1, 1995Paper

Endocrinological and histological changes after treatment of uterine leiomyomas with danazol or buserelin

The Journal of Obstetrics and Gynaecology
M UekiO Sugimoto

Abstract

The following results were obtained from our investigations performed to compare the effects of danazol (400 mg/day orally for 4 to 6 months, n = 164) with those of buserelin (900 micrograms/day intranasally for 4 to 6 months, n = 83) on patients with uterine myomas. The effectiveness of buserelin (76.1%) in shrinking uterine myomas was better than that of danazol (56.7%). The serum-estradiol and progesterone levels were lower in the buserelin group than in the danazol group. The estrogen and progesterone receptors in a hysterectomied uterus were positively stained even at the end of those therapies. The degree and frequency of hyaline degeneration were higher in the buserelin group than in the danazol group. Thus, the shrinking of uterine myomas and the degree of hyaline degeneration might be caused by the lowering of uterine-tissue hormones, particularly of estradiol levels.

References

Jun 1, 1990·Gynecologic Oncology·T YamamotoH Okada

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Citations

Nov 11, 2011·Journal de gynécologie, obstétrique et biologie de la reproduction·M KoskasJ Derrien
Feb 19, 1999·Baillière's Clinical Obstetrics and Gynaecology·T Eldar-Geva, D L Healy
Aug 19, 2015·Gynecological Surgery·Elizabeth A PrittsDavid L Olive
Jan 23, 1999·American Journal of Obstetrics and Gynecology·P M O'Brien, I E Abukhalil
Jan 18, 2005·Fertility and Sterility·Bradley S HurstPaul B Marshburn
Jul 10, 2009·The Cochrane Database of Systematic Reviews·Lin-Qiu KeChun-Mei Li
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Yan ZhangZhishun Liu
Sep 14, 2002·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·K W Schweppe

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