PMID: 11915368Mar 28, 2002Paper

Endocrinological assessment of toxic effects on the male reproductive system in rats treated with 5-fluorouracil for 2 or 4 weeks

The Journal of Toxicological Sciences
Setsuko Takizawa, I Horii

Abstract

Endocrinological assessment of male reproductive toxicity was carried out in SD-Slc male rats treated with 5-FU (0, 20, 30 mg/kg/day) orally for 2-week or 4-week term. Serum hormone levels including GnRH, FSH, LH, prolactin, total and free testosterone, inhibin B, pro-alpha C, and activin A were determined as well as histopathological examination of the reproductive organs. The 5-FU treated groups showed histopathological changes in the testis such as degeneration of seminiferous epithelium. An obvious decrease in serum testosterone level was observed with a reduced organ weight of the seminal vesicle and prostate. However, no significant changes were noted in serum LH or FSH levels, nor in the morphological examination of the Leydig cells. Decreased serum levels were noted in activin A and prolactin. An increased serum level was noted in GnRH and pro-alpha C whose synthesis is regulated by FSH. Serum inhibin B levels showed a tendency toward decreasing with morphological change (vacuolation) in Sertoli cells. These results indicated that male reproductive toxicity induced by 5-FU would be augmented by decreased serum prolactin and testosterone levels as well as a decreased function of Sertoli cell, in addition to the direct cy...Continue Reading

References

Oct 1, 1991·The American Journal of Anatomy·L D Russell, J A Russell
Oct 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M Pinedo, G F Peters
Feb 1, 1971·The Journal of Endocrinology·A Bartke
May 1, 1982·Endocrinology·G B Ellis, C Desjardins
Jan 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·I StupansM T McClure
Jun 1, 1995·Biology of Reproduction·E HondoY Hayashi
Oct 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·C D BrownM G Miller

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Citations

Aug 11, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S HenniesH Christiansen
Dec 20, 2008·International Journal of Radiation Oncology, Biology, Physics·Frederick H YoonLarry Stitt
May 10, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Robert M HermannHeinz Schmidberger
Nov 12, 2016·The EPMA Journal·Mohsin H K RoshanNikolai P Pace
Jan 1, 2008·Clinical Medicine. Oncology·Syed Imam RabbaniSalma Khanam
Aug 21, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardSeyed Abdulmajid Ayatollahi

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