Endocrinopathies in patients with transfusion-dependent beta-thalassemia

Pediatric Hematology and Oncology
A MehrvarP Vossough

Abstract

Thalassemia is common in Iran. Appropriate therapy for this disease includes a regular blood transfusion and chelation therapy. However, in this approach patients will inevitably experience side effects, particularly iron overloads in critical organs, including heart, ductless glands, and liver. This study attempted to determine prevalence of adenoidal abnormality between Iranian thalassemia patients for prediagnosis and to offer necessary medical measures. This is a descriptive nonrandomized study and included all the patients suffering from thalassemia major referring to medical centers linked with the Iranian blood transfusion organization from January 2004 to January 2005. All patients were sampled for CBC, FBS, 2-h BS, HbAlC, liver function, renal function, and endocrine disease. Initially, reports of adenoidal experiments as well as other associated parameters were provided from medical records. A total of 437 patients enrolled in the study: 5.4% suffered from diabetes, 1% had hypothyroid, and 1 person showed hypoparathyroidism. The mean levels of ferritin in diabetic and nondiabetic groups and hypothyroid and nonhypothyroid groups were not significantly different. The mean levels of ferritin among various age groups also...Continue Reading

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Citations

Aug 28, 2010·Pediatric Hematology and Oncology·Masood BazrgarMehran Karimi
Apr 3, 2015·BioMed Research International·Adlette InatiHussein A Abbas
Jan 1, 2014·The Journal of the Egyptian Public Health Association·Abdel-Rahman A Abdel-RazekEman R Youness
May 29, 2020·Biological Trace Element Research·Ayşe ŞahinSezgin Bakırdere

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