Endocrinopathy, vision, headache, and recurrence after transsphenoidal surgery for Rathke cleft cysts

Neurosurgery
Scott D WaitWilliam L White

Abstract

Rathke cleft cyst can enlarge and become symptomatic. To review the clinical data and results of all patients treated by the senior author for a Rathke cleft cyst. A prospectively maintained surgical database, supplemented with updates from telephone conversations, of all patients presenting to the Barrow Neurological Institute from 1992 to the present was reviewed. Seventy-three patients (17 males, 56 females; mean age, 40 years; range, 5-80 years) underwent 77 resections. The mean length of follow-up was 27 months (range, 0-129 months). Presenting symptoms included headache (75%), followed by endocrinopathy (49%), and visual symptoms (39%). Preoperative chiasmopathy resolved in 75% and improved in 21% of the patients. Patients' preoperative endocrinopathy resolved at various rates, depending on the specific axis (29%-100%). Endocrinopathies were more likely to resolve in females than males. New postoperative endocrinopathies also occurred (0-8%). Headache resolved (68%) or improved (21%) in most patients. No patient had worsened headaches. Eight patients had a recurrence, 4 of whom underwent reoperation. The presence of squamous metaplasia was the only predictor of recurrence. Surgical fenestration and/or resection of Rathke ...Continue Reading

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Citations

Jul 5, 2011·Neurosurgical Focus·Dominique M HigginsFredric B Meyer
Sep 24, 2013·Journal of Neurosurgery·Jun FanJun Pan
Nov 26, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Zachary S MendelsonJames K Liu
May 6, 2014·Clinical Neurology and Neurosurgery·Chih-Hsiang LiaoYang-Hsin Shih
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Nov 8, 2012·Journal of Korean Neurosurgical Society·Ealmaan Kim
Feb 17, 2015·BioMed Research International·Yukai SuAkio Morita
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Jul 10, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yasuhiko HayashiMitsutoshi Nakada
Dec 3, 2020·British Journal of Neurosurgery·Ivan CabriloNeil L Dorward

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