Endocytosis in sickle erythrocytes: a mechanism for elevated intracellular Ca2+ levels

Journal of Cellular Physiology
E RubinP Williamson

Abstract

Staining of sickle cells with the fluorescent probes chlortetracycline (a Ca2+ probe) and diindocarbocyanine (a general membrane probe) revealed the presence of Ca2+-containing vesicles which are not found in normal erythrocytes. These vesicles increase in number upon deoxygenation, and are apparently formed by endocytosis, as judged by the use of the extracellular fluorescent probe lucifer yellow. The presence of vesicles is not restricted to any particular morphological or density class of cells in the general population.

References

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Citations

Jan 1, 1987·The Journal of Membrane Biology·B Engelmann, J Duhm
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Jul 1, 1992·Journal of Cellular Physiology·P WilliamsonR A Schlegel

Related Concepts

Anemia, Sickle Cell
Calcium
Chlortetracycline Sulfate (2: 1)
Endocytosis
Erythrocytes
Staining and Labeling

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