Endocytosis in sickle erythrocytes: a mechanism for elevated intracellular Ca2+ levels

Journal of Cellular Physiology
E RubinP Williamson


Staining of sickle cells with the fluorescent probes chlortetracycline (a Ca2+ probe) and diindocarbocyanine (a general membrane probe) revealed the presence of Ca2+-containing vesicles which are not found in normal erythrocytes. These vesicles increase in number upon deoxygenation, and are apparently formed by endocytosis, as judged by the use of the extracellular fluorescent probe lucifer yellow. The presence of vesicles is not restricted to any particular morphological or density class of cells in the general population.


Jan 1, 1977·British Journal of Haematology·J Palek
Jan 1, 1979·International Review of Cytology·A H Caswell
May 1, 1985·Journal of Cellular Physiology·P WilliamsonR A Schlegel
May 1, 1985·Journal of Cellular Physiology·R A SchlegelP Williamson
Nov 9, 1973·Nature·J W EatonH S Jacob
Dec 1, 1983·The Journal of Cell Biology·D K MillerR A Firestone
Apr 1, 1984·British Journal of Haematology·M P WestermanK Wu
Mar 1, 1981·British Journal of Haematology·D AllanM P Westerman
Mar 1, 1983·British Journal of Haematology·L M SnyderN L Fortier
May 1, 1980·The New England Journal of Medicine·R P HebbelM H Steinberg


Jan 1, 1987·The Journal of Membrane Biology·B Engelmann, J Duhm
Nov 1, 1986·The Journal of Clinical Investigation·S M WaughP S Low
Sep 1, 1987·Baillière's Clinical Haematology·J Stuart, C S Johnson
Dec 1, 1996·Hematology/oncology Clinics of North America·S K Ballas, N Mohandas
Mar 1, 1997·American Journal of Hematology·M P WestermanP Williamson
Dec 25, 2004·Physiological Reviews·Virgilio L Lew, Robert M Bookchin
Jul 1, 1992·Journal of Cellular Physiology·P WilliamsonR A Schlegel

Related Concepts

Anemia, Sickle Cell
Chlortetracycline Sulfate (2: 1)
Staining and Labeling

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.


Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.