Endocytosis of G Protein-Coupled Receptors and Their Ligands: Is There a Role in Metal Trafficking?

Cell Biochemistry and Biophysics
Katerina ChristofidesChristopher E Jones

Abstract

The prevalence of metal dysregulation in many neurodegenerative and neurocognitive disorders has compelled many studying such diseases to investigate the mechanisms underlying metal regulation in the central nervous system. Metal homoeostasis is often complex, with sophisticated, multilayered pathways in operation. G protein-coupled receptors are omnipresent on cell membranes and have intriguing mechanisms of endocytosis and trafficking that may be useful in metal homoeostasis. Indeed, many receptors and/or their cognate ligands are able to bind metals, and in many cases metals are considered to have neuromodulatory roles as a result of receptor binding. In this mini-review, we outline the structural and functional aspects of G protein-coupled receptors with a focus on the mechanisms leading to endocytosis and cellular trafficking. We further highlight how this may help in the trafficking of metal ions, notably copper.

References

May 7, 1990·Biochimica Et Biophysica Acta·L BirnbaumerA M Brown
Apr 5, 1996·The Journal of Biological Chemistry·K ThirstrupT W Schwartz
Jan 27, 1998·The Journal of Biological Chemistry·A PizardR M Rajerison
Jul 11, 1998·The Journal of Biological Chemistry·U Gether, B K Kobilka
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·A ClaingR T Premont
Oct 3, 2002·Nature Reviews. Drug Discovery·Susan R GeorgeSamuel P Lee
Nov 1, 2002·The Journal of Biological Chemistry·Gayathri SwaminathBrian Kobilka
Nov 14, 2002·Pharmacological Reviews·Zhong Ming QianKwokping Ho
Dec 3, 2003·The Journal of Biological Chemistry·Dennis K LeeBrian F O'Dowd
Dec 13, 2003·Endocrine Reviews·Theresa M Cabrera-VeraHeidi E Hamm
Jun 28, 2005·Cytokine & Growth Factor Reviews·Jean-Yves SpringaelMarc Parmentier
Apr 13, 2006·Blood·Robert S OhgamiMark D Fleming
Dec 26, 2006·Biochimica Et Biophysica Acta·Brian K Kobilka
Jan 15, 2008·British Journal of Pharmacology·A B Tobin
Mar 5, 2008·Journal of Neurochemistry·Cecilia I Calero, Daniel J Calvo
Apr 4, 2008·Trends in Pharmacological Sciences·Vsevolod V Gurevich, Eugenia V Gurevich
Apr 26, 2008·Journal of Receptor and Signal Transduction Research·Benoit BoivinTerence E Hébert
May 22, 2009·Nature·Daniel M RosenbaumBrian K Kobilka
Dec 24, 2009·Current Pharmaceutical Design·Stefano CostanziKenneth A Jacobson
Mar 23, 2010·Trends in Pharmacological Sciences·Davide CalebiroMartin J Lohse
May 1, 2010·Nature Reviews. Drug Discovery·Sudarshan RajagopalRobert J Lefkowitz
Oct 14, 2010·The Journal of Biological Chemistry·Erik G HofmanPaul M P van Bergen en Henegouwen
Nov 26, 2010·The Journal of Biological Chemistry·Rafal Robert NazarewiczR Wayne Alexander
Dec 8, 2010·Journal of Inorganic Biochemistry·Kimon ZavitsanosNick Hadjiliadis
Jan 5, 2011·Nature Reviews. Drug Discovery·Rosamaria Lappano, Marcello Maggiolini
Feb 26, 2011·The Biochemical Journal·Jian Wang, Kostas Pantopoulos
May 4, 2011·Journal of Cell Science·Amanda Reider, Beverly Wendland
Jun 18, 2011·Trends in Pharmacological Sciences·Sudha K Shenoy, Robert J Lefkowitz
Jun 24, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Francis W FlynnZhaojie Zhang
Jul 21, 2011·Nature·Søren G F RasmussenBrian K Kobilka
Jul 23, 2011·Nature Reviews. Molecular Cell Biology·Harvey T McMahon, Emmanuel Boucrot
Aug 30, 2011·Nature Chemical Biology·Kou QinNevin A Lambert
Nov 15, 2011·Current Biology : CB·Richard A Festa, Dennis J Thiele
Mar 10, 2012·Advanced Drug Delivery Reviews·David Hymel, Blake R Peterson
Jun 19, 2012·Current Biology : CB·Filipe FerreiraElizabeth Smythe
Oct 3, 2012·Advanced Drug Delivery Reviews·Shi XuSarah F Hamm-Alvarez

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
GTPases
co-immunoprecipitation
nuclear translocation

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

The Journal of Biological Chemistry
M Vaughan
Seikagaku. The Journal of Japanese Biochemical Society
Junko Y Toshima, Jiro Toshima
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
So Iwata, Momi Iwata
© 2022 Meta ULC. All rights reserved