Sep 1, 1994

Endocytosis of the beta chain of interleukin-2 receptor requires neither interleukin-2 nor the gamma chain

European Journal of Immunology
A HémarA Dautry-Varsat

Abstract

Interleukin-2 (IL-2) and IL-2 receptors (IL-2R) critically regulate the magnitude and duration of T cell expansion required in an immune response. Modulation occurs at the level of receptor number and affinity. IL-2R is a multisubunit receptor which contains at least three chains, IL-2R alpha (p55), IL-2R beta (p70) and IL-2R gamma (p64). Some components of high-affinity receptors (alpha beta gamma) are continuously internalized in the absence as well as in the presence of IL-2. From studies on other receptors, it is known that endocytosis of ligand-receptor complexes is due to an intrinsic property of the receptor. However, the specific chains responsible for endocytosis of high-affinity IL-2 receptors have not been fully elucidated. IL-2R gamma has been reported to be necessary for IL-2 internalization, based on the fact that fibroblasts transfected with IL-2R alpha and -beta do not internalize IL-2. However, IL-2 dissociates too rapidly from IL-2R alpha beta receptors to allow for its internalization. From the reported results on IL-2 internalization in transfected fibroblasts, it cannot be concluded as to the respective roles of IL-2R beta and/or IL-2R gamma in endocytosis. As modulation of receptor number is important for ...Continue Reading

Mentioned in this Paper

Monoclonal Antibodies
Endocytosis
IL2
Lymphoid Cells
RU 49637
Histiocytic Medullary Reticulosis (Disorder)
X-Linked Combined Immunodeficiency Diseases
Cell Line, Transformed
Tumor Cells, Cultured
IL2RA

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