Endoderm convergence controls subduction of the myocardial precursors during heart-tube formation

Development
Ding YeFang Lin

Abstract

Coordination between the endoderm and adjacent cardiac mesoderm is crucial for heart development. We previously showed that myocardial migration is promoted by convergent movement of the endoderm, which itself is controlled by the S1pr2/Gα13 signaling pathway, but it remains unclear how the movements of the two tissues is coordinated. Here, we image live and fixed embryos to follow these movements, revealing previously unappreciated details of strikingly complex and dynamic associations between the endoderm and myocardial precursors. We found that during segmentation the endoderm underwent three distinct phases of movement relative to the midline: rapid convergence, little convergence and slight expansion. During these periods, the myocardial cells exhibited different stage-dependent migratory modes: co-migration with the endoderm, movement from the dorsal to the ventral side of the endoderm (subduction) and migration independent of endoderm convergence. We also found that defects in S1pr2/Gα13-mediated endodermal convergence affected all three modes of myocardial cell migration, probably due to the disruption of fibronectin assembly around the myocardial cells and consequent disorganization of the myocardial epithelium. Moreov...Continue Reading

References

Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Dec 2, 1999·Genes & Development·J F ReiterD Y Stainier
Sep 2, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chiu-Ju HuangHuai-Jen Tsai
Mar 20, 2004·Developmental Cell·L A Trinh, Didier Y R Stainier
Mar 25, 2005·Current Biology : CB·Le A TrinhDidier Y R Stainier
Feb 3, 2006·Development·Jelena S ArnoldBernice E Morrow
Jan 19, 2007·Nature Clinical Practice. Cardiovascular Medicine·Takaaki MatsuiJuan Carlos Izpisúa Belmonte
Jun 1, 2007·Development·Nathalia Glickman HoltzmanDeborah Yelon
Aug 29, 2007·PLoS Genetics·Jeroen BussmannStefan Schulte-Merker
Oct 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kristen M KwanChi-Bin Chien
Oct 20, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jacques A VillefrancNathan D Lawson
Apr 24, 2008·Development, Growth & Differentiation·Wataru Shoji, Mika Sato-Maeda
Mar 13, 2009·Development·Lara CarvalhoCarl-Philipp Heisenberg
Jun 6, 2009·Developmental Biology·Cheng CuiBrenda J Rongish
Aug 21, 2010·Development·Zayra V Garavito-AguilarDeborah Yelon
Dec 15, 2010·Circulation Research·Sylvia M EvansMargaret L Kirby
May 24, 2011·Cardiovascular Research·Jeroen Bakkers
Jul 12, 2011·Annual Review of Cell and Developmental Biology·Thomas LecuitEdwin Munro
Nov 29, 2011·Developmental Biology·Kuan Shen WongSaulius Sumanas
Sep 5, 2012·The Journal of Cell Biology·Stephanie WooDidier Y R Stainier
Sep 15, 2012·Annual Review of Genetics·David Staudt, Didier Stainier
Feb 5, 2013·Developmental Cell·Chong Pyo ChoeJ Gage Crump
Sep 21, 2013·Nature Reviews. Genetics·Callie Johnson Miller, Lance A Davidson
May 9, 2015·Developmental Biology·Anastasiia AleksandrovaBrenda J Rongish

❮ Previous
Next ❯

Citations

Sep 12, 2019·Thyroid : Official Journal of the American Thyroid Association·Benoit HaerlingenSabine Costagliola
Jan 31, 2020·Journal of Cardiovascular Pharmacology·Shuang ZhouKun Sun
Jan 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Granton A JindalStanislav Y Shvartsman
Oct 1, 2021·The Journal of Cell Biology·Bo HuFang Lin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.