Nov 1, 1989

Endodermal sinus tumor of the ovary: a paradoxical response to chemotherapy

Gynecologic Oncology
R YazigiA Muñoz

Abstract

A patient with ovarian endodermal sinus tumor metastatic to the liver responded unusually to chemotherapy. She experienced histologically documented regression of all intraperitoneal disease with the exception of the liver metastases when given vinblastine, bleomycin, and cisplatin. She eventually died of liver failure. A review of patients with ovarian endodermal sinus tumor who either presented with initial liver metastases or had recurrent disease in the liver leads us to conclude that the liver is a preferential site for spread, that liver metastases carry an ominous prognosis, and that failure to see prompt liver metastatic tumor response after systemic chemotherapy should signal a need for a more aggressive therapeutic approach to the liver lesions.

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Mentioned in this Paper

Vinblastine
Dermatofibrosarcoma Protuberans
Ovarian Neoplasm
Bleomycin
Antineoplastic Chemotherapy Protocols
Secondary Malignant Neoplasm of Liver
Liver Failure
Bleomicina
Endodermal Sinus Tumor of Ovary
Cisplatin

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