Endodontic pathogens stimulate monocyte chemoattractant protein-1 and interleukin-8 in mononuclear cells

Journal of Endodontics
Y JiangD T Graves

Abstract

Microbial infection of the dental pulp leads to the recruitment of leukocytes and the formation of lesions of endodontic origin. The chemokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) are relatively specific chemoattractants for neutrophils and monocytes, respectively. In the present studies, peripheral blood mononuclear cells were stimulated by Streptococcus mutants, Porphyromonas endodontalis, and Peptostreptococcus anaerobius, which are associated with lesions of endodontic origin. Each of these bacteria induced a dose-dependent increase in IL-8 and MCP-1, determined by ELISA. The levels induced are physiologically relevant. However, low doses of P. endodontalis were less effective in inducing IL-8 or MCP-1 expression, compared with S. mutants or P. anaerobius. Thus, these bacteria can induce significant levels of the chemokines IL-8 and MCP-1, which could contribute to the recruitment of neutrophils or monocytes in vivo. The expression of these mediators may contribute to the development of endodontic infections, particularly with regard to inflammatory leukocyte recruitment.

References

Apr 1, 1992·Journal of Endodontics·B E WaymanC B Fowler
Sep 1, 1985·Infection and Immunity·A J van WinkelhoffJ de Graaff
Jan 1, 1995·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·D T Graves, Y Jiang
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Jun 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Tanner, N Stillman

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Citations

Sep 20, 2011·Journal of Endodontics·Ya-Yun LeeShue-Fen Yang
Nov 5, 2003·Clinical Lung Cancer·Santiago Ballaz, James L Mulshine
May 19, 2007·Journal of Endodontics·Chin-Lo Hahn, Frederick R Liewehr
May 5, 2005·Biochimica Et Biophysica Acta·Julia L McLachlanPaul R Cooper
Mar 2, 2011·Brazilian Oral Research·Bruno Neves CavalcantiMárcia Martins Marques
Dec 12, 2001·Oral Microbiology and Immunology·G RosenM N Sela
Nov 26, 2009·Journal of Applied Oral Science : Revista FOB·Alessandra Cecília Oliveira SilvaBruno Neves Cavalcanti
Apr 26, 2018·Frontiers in Pharmacology·Cynthia J Henley-SmithNamrita Lall

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