Endogeneous remyelination: findings in human studies.

CNS & Neurological Disorders Drug Targets
Markus KippRobin J M Franklin

Abstract

In multiple sclerosis, conduction block in demyelinated axons underlies early neurological symptoms, whereas axonal transection is believed to be responsible for more permanent later deficits. Approved treatments for the disease are immunoregulatory and reduce the rate of lesion formation and clinical exacerbation, but are only partially effective in preventing the onset of disability. Remyelination is a term for the re-generation of the nerve's myelin sheath and is a subject of active medical research. Remyelination capacity varies from patient to patient or even from lesion to lesion in one and the same patient. Efforts to understand the causes for remyelination failure have prompted research into the biology of remyelination and the complex molecular factors that regulate remyelination. In the current review article we address challenges of remyelination research with a special focus on histo-pathological studies using brain biopsy and autopsy material. We summarize our current knowledge about extent of remyelination in multiple sclerosis patients and its relation to disease duration, lesion type, inflammation, affected brain region and gender. Furthermore we will address which step(s) of the oligodendrocyte maturation progr...Continue Reading

Citations

Jul 11, 2013·Clinical & Developmental Immunology·Khalil S Rawji, V Wee Yong
Dec 24, 2015·Frontiers in Neurology·Danielle E HarlowAugusto A Miravalle
Oct 29, 2013·Neuroscience·S Wang, K M Young
Nov 25, 2014·Cellular and Molecular Life Sciences : CMLS·Markus KippOmid Nikoubashman
Jun 21, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·J Matías-GuíuU Gomez-Pinedo
Aug 24, 2016·Frontiers in Cell and Developmental Biology·Helena S DominguesJoão B Relvas
Dec 17, 2019·Current Pharmaceutical Design·Rodrigo Varas, Fernando C Ortiz
Aug 1, 2020·Frontiers in Neurology·Jorge Matías-GuiuUlises Gómez-Pinedo
Apr 5, 2018·Frontiers in Molecular Neuroscience·José J Miguel-Hidalgo
Feb 9, 2021·Biochemistry and Biophysics Reports·Sajad HassanzadehSeyed Mohammad Davachi
Feb 18, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laetitia PouzolMarianne M Martinic

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