PMID: 8969942Nov 1, 1996Paper

Endogenous 11 beta-hydroxysteroid dehydrogenase inhibitors and their role in glucocorticoid Na+ retention and hypertension

Endocrine Research
D J Morris, G W Souness

Abstract

11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) metabolizes active glucocorticoids to their inactive 11-dehydro products and protects renal mineralocorticoid receptors from the high circulating levels of endogenous glucocorticoids. 11 beta-HSD has been suggested to be important not only in the control of renal sodium retention but also blood pressure. We had previously shown that 11 alpha- and 11 beta-hydroxyprogesterone (11 alpha- and 11 beta-OHP) were (I) potent inhibitors of 11 beta-HSD (Isoforms 1 and 2) activity in vitro, (ii) able to confer mineralocorticoid (MC) activity upon corticosterone (B) in vivo and (iii) hypertensinogenic when chronically infused into Sprague-Dawley (SD) rats. In addition we also showed that 3 alpha,5B-tetrahydroprogesterone (3 alpha,5B-THP) and chenodeoxycholic acid (CDCA) were potent inhibitors of 11 beta-HSD1 activity but not 11 beta-HSD2 activity, however, these substances were still able to confer MC activity upon B in the adrenalectomized rat. To assess the possible blood pressure modulating effects of 3 alpha,5B-THP and CDCA we have now infused these substances into intact SD rats continuously for 14 days. Both 3 alpha,5B-THP and CDCA caused a significant elevation in blood pressure wit...Continue Reading

References

Nov 1, 1979·The Journal of Clinical Endocrinology and Metabolism·S UlickM I New

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Citations

Nov 7, 2001·The Journal of Clinical Investigation·C QuattropaniF J Frey
Feb 19, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bing YaoMing-Zhi Zhang
Jun 7, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rasoul Alikhani-KoupaeiFelix J Frey
Feb 26, 2009·British Journal of Pharmacology·Patrick W F HadokeBrian R Walker
Oct 28, 2019·World Journal of Surgical Oncology·Yaqin ZhangMingwei Chen
Jun 13, 2002·European Journal of Clinical Investigation·A AudigéB Vogt
Feb 19, 2021·Circulation Research·Huanan ShiDavid J Durgan
Jun 5, 2003·Molecular and Cellular Endocrinology·David J MorrisMatthew P Hardy
Sep 29, 2005·Molecular and Cellular Endocrinology·Syed A LatifDavid J Morris

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