Endogenous 5-HT(1/2) systems and the newborn rat respiratory control. A comparative in vivo and in vitro study

Respiratory Physiology & Neurobiology
L BodineauA Frugière

Abstract

Consequences of 5-HT(1/2) systems blockade by methysergide on newborn rats respiratory drive were evaluated in vivo with unrestrained animals and in vitro using brainstem-spinal cord preparations. A decrease in respiratory frequency until a plateau level was observed under both in vivo (82.8 +/- 0.6% of control values) and in vitro (76.8 +/- 0.8% of control values) conditions whereas an increase in inspiratory amplitude (135.1 +/- 2.1% of control values) was only retrieved in vivo. By the use of the c-fos expression analysis, we correlated these effects with neuronal activity changes, particularly, in vivo in two key structures between the respiratory ponto-medullary network and the peripheral or suprapontine afferences, namely the commissural subnucleus of the nucleus of the solitary tract and the lateral parabrachial nucleus. Thus, peripheral and suprapontine inputs seem to be of a primeval importance in the respiratory influence of endogenous 5-HT. Besides, as 5-HT is involved in the respiratory perturbations that occur in sudden infant death syndrome (SIDS), our results suggest a participation of peripheral and suprapontine inputs in these disorders.

References

Jul 1, 1992·Journal of Neuropathology and Experimental Neurology·J J Filiano, H C Kinney
Nov 22, 1990·The Journal of Comparative Neurology·S Manaker, H M Verderame
Mar 15, 1990·The Journal of Comparative Neurology·J J FilianoH C Kinney
Nov 8, 1987·The Journal of Comparative Neurology·K B Thor, C J Helke
Sep 1, 1989·Journal of Neuroscience Methods·M Dragunow, R Faull
Jul 1, 1985·Clinical and Experimental Pharmacology & Physiology·R L Martin-Body, H R Grundy
Oct 1, 1970·Respiration Physiology·D Bartlett, S M Tenney
Jul 15, 1994·Brain Research. Developmental Brain Research·E Di PasqualeG Hilaire
Feb 1, 1993·The Journal of Physiology·A D Lindsay, J L Feldman
Apr 4, 1998·Pflügers Archiv : European journal of physiology·H OnimaruI Homma
Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
Nov 17, 1999·The European Journal of Neuroscience·J Khater-BoidinB Duron
Jul 31, 2001·Trends in Neurosciences·D W Richter, K M Spyer
Jul 11, 2002·Respiratory Physiology & Neurobiology·Jan-Marino RamirezDonald R McCrimmon

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Citations

Nov 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul A GrayChristopher A Del Negro
Jun 9, 2005·Respiratory Physiology & Neurobiology·Claude Gaultier, Jorge Gallego
Oct 19, 2011·The Journal of Physiology·Robert T R Huckstepp, Nicholas Dale
Jun 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lei ZhaoFadi Xu

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