Endogenous acetylcholine modulates impulsive action via alpha4beta2 nicotinic acetylcholine receptors in rats

European Journal of Pharmacology
Iku Tsutsui-KimuraMitsuhiro Yoshioka

Abstract

Nicotine has been well established as an impulsive action-inducing agent, but it remains unknown whether endogenous acetylcholine affects impulsive action via nicotinic acetylcholine receptors. In the present study, the 3-choice serial reaction time task (3-CSRTT), a simple and valid assessment of impulsive action, was employed. Male Wistar/ST rats were trained to detect and respond to 1-s flashes of light presented in one of three holes until stable performance was achieved. Following training on the 3-CSRTT, rats received intracerebroventricular injections of the preferential alpha4beta2 nicotinic acetylcholine receptor antagonist dihydro-beta-erythroidine (DHbetaE; 0, 3, 10, and 30 microg) or the selective alpha7 nicotinic acetylcholine receptor antagonist methyllycaconitine (MLA; 0, 3, 10, and 30 microg) 5 min before test sessions. Injection of 10 microg of DHbetaE significantly suppressed premature responses, an index of impulsive-like action, without changing other behavioral parameters. On the other hand, MLA infusions failed to affect impulsive-like action at any dose. These results suggest that the central alpha4beta2 nicotinic acetylcholine receptors that enable a provoking effect of endogenous acetylcholine play a cr...Continue Reading

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Citations

Apr 20, 2011·Psychopharmacology·Katerina Zoe KolokotroniAmanda A Harrison
Sep 29, 2011·Psychopharmacology·Yu OhmuraMitsuhiro Yoshioka
Oct 18, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roel J T MockingCatherine J Harmer
Oct 1, 2014·Translational Psychiatry·S KhadkaG D Pearlson
Nov 4, 2015·Frontiers in Behavioral Neuroscience·Matthew O ParkerCaroline H Brennan
May 28, 2013·Journal of Pharmacological Sciences·Yu OhmuraMitsuhiro Yoshioka
Mar 27, 2012·Journal of Pharmacological Sciences·Yu OhmuraMitsuhiro Yoshioka
Oct 7, 2018·Annals of the New York Academy of Sciences·Karolina KozakTony P George
May 29, 2014·British Journal of Pharmacology·B Jupp, J W Dalley
Jul 21, 2020·Journal of Psychopharmacology·Javier Íbias, Arbi Nazarian

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